Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density

EO Gracheva, G Hadwiger, ML Nonet, JE Richmond - Neuroscience letters, 2008 - Elsevier
… by a reduction in docked vesicles adjacent to the presynaptic density. … vesicle-associated
GTPase Rab3A, here we asked whether UNC-10-dependent recruitment of synaptic vesicles to …

Defective neuromuscular junction organization and postnatal myogenesis in mice with severe spinal muscular atrophy

E Dachs, M Hereu, L Piedrafita… - … of Neuropathology & …, 2011 - academic.oup.com
removal of nerve terminals from the postsynaptic sites (Fig. 6H). … (J) Quantification of the
number of synaptic vesicles docked at … fall in Rab3A and CGRP, whereas other synaptic vesicle

Rab3A Small G Protein and Its Regulators in Neurotransmitter Release and Synaptic Plasticity

H Nakanishi, T Sasaki, J Miyoshi, Y Takai - … Research: From Molecular …, 2002 - Springer
… Studies on Rab3A knockout mice have revealed that Rab3A … and docking of synaptic vesicles
to the active zone. GTP-… action potentials of the diaphragm and gastrocunemius muscles in …

APP anterograde transport requires Rab3A GTPase activity for assembly of the transport vesicle

A Szodorai, YH Kuan, S Hunzelmann… - Journal of …, 2009 - Soc Neuroscience
… FAT rates might be altered by deletion of the APP C-terminus, … , we performed
immunoisolations from crude mouse brain … in various aspects of synaptic vesicle fusion. Thus, our …

Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses

ZP Pang, E Melicoff, D Padgett, Y Liu… - Journal of …, 2006 - Soc Neuroscience
… of the diaphragm; this pattern is controlled by synaptic activity, … of the deletion of
synaptotagmin-2 on synaptic transmission, we … of vesicle release but not the filling or fusion of …

Regulation of quantal shape by Rab3A: evidence for a fusion pore‐dependent mechanism

X Wang, R Thiagarajan, Q Wang… - The Journal of …, 2008 - Wiley Online Library
mice are only reduced 50%. These results indicate that Rab3 proteins are not essential for
synaptic vesicle fusion… indicated that Rab3A deletion would have an effect on the shape of a …

Loss of laminin‐a4 results in pre‐and postsynaptic modifications at the neuromuscular junction

KK Chand, KM Lee, NA Lavidis… - The FASEB …, 2017 - Wiley Online Library
… not only a decrease in the availability of synaptic vesicles from the … number of docked vesicles
in Rab3A-knockout mice (66), a … ) Rab3a deletion reduces vesicle docking and transmitter

Acrosomal swelling and membrane docking are required for hybrid vesicle formation during the human sperm acrosome reaction

N Zanetti, LS Mayorga - Biology of reproduction, 2009 - academic.oup.com
RAB3A is necessary for an early step of acrosomal exocytosis [18], … in docking in mouse
diaphragm synapse [53]; hence, GDIα, which sequesters RAB3, should negatively affect docking

GTP-bound Rab3A exhibits consecutive positive and negative roles during human sperm dense-core granule exocytosis

MA Bustos, CM Roggero… - Journal of molecular …, 2014 - academic.oup.com
Rab3A halts exocytosis when added after the docking of the … effects of Rab3A deletion on
synaptic transmission appear to … Rab3A would be to escort a vesicle to the zone of release

Rab3A negatively regulates activity‐dependent modulation of exocytosis in bovine adrenal chromaffin cells

R Thiagarajan, T Tewolde, Y Li… - The Journal of …, 2004 - Wiley Online Library
… by stopping down the field diaphragm to its minimum, a … Rab3A is absent, as in a genetic
deletion. Two findings in the … synapses of the Rab3A-, GDI-, GEP- and RIM-knockout mice, …