… Genetic deletion of munc18-1 and most other SM genes … analyzed diaphragm NMJs of
Munc18-1-overexpressing mice (… protein Rab3A regulates a late step in synaptic vesicle fusion. …

… C2B domain deletion mutants (ie mRFP… mice demonstrated that synaptic vesicle rabphilin
directly binds to SNAP-25 and regulates the docking process and the neurotransmitter release …

… deletion of three isoforms leads to lethality if Rab3A is one of the deleted genes in mice [70]. …
This triggers the fusion of synaptic vesicles containing approximately 200mM glutamate …

… protein receptors, which mediate vesicle fusion, have also been identified as … mouse
Rab3a resistant to the shRNA used to silence Rab3a. Overexpression of mouse GFP-Rab3a …

… of synaptic vesicles is preceded by the docking of vesicles to … chromaffin cells was reduced
by the deletion of SNAP25 (135)… of the fusion pore or to stable hemifusion diaphragms (402). …

… and central synapses: 0.147 μm 2 for rat diaphragm NMJs [23]… knockout mice, the number
of docked synaptic vesicles per … these microdeletions identified common deletions in the ELKS …

… processing of neuropeptides, removal of membrane) while … Rab3a, Rab3b, Rab3c, and
Rab27b) involved in docking and … Rupture of this diaphragm leads to the opening of a fusion …

… fusion and release of synaptic vesicles within the motor nerve terminal and manifested in
decreased quantal content and reduced … examined evoked transmitter release under conditions …

… Although SNAREs are believed to be essential for vesicle fusion, synaptic vesicle fusion is
not … RIM binds to munc13 and interacts with rab3A. Deletion of RIM1α does not have a strong …

… synaptic-vesicle cycle, including a key function between the … function have focused on deletion
mutants or peptides, but as … this site of contact (the 'hemifusion diaphragm') and the ring is …