Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update

R Abinaya, S Srinath, S Soundarya, R Sridhar… - Journal of Molecular …, 2022 - Elsevier
… , we highlight the recent developments and studies related to the design and synthesis of
β-… Furthermore, various derivatives of β-carboline with important biological activities which …

β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities

J Dai, W Dan, U Schneider, J Wang - European Journal of Medicinal …, 2018 - Elsevier
activity relationship (SAR) and mechanism of their biological … In this section, highlighted
biological activities of β-carboline … development are discussed based on the structure−activity

Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins

CH Yao, TC Hsieh, JS Song, JC Lee - Future Medicinal Chemistry, 2020 - Taylor & Francis
studies of their biological activities have yet to be reported. … A solution of β-carbolin-1-one
thiohydantoin 5a (105 mg, 0.24 … , we studied their related structureactivity relationship by the …

Development in the Synthesis and Biological Activities of THβ-carboline and Its Analogs

N Bejigo, AM Yadessa - … of Science and Sustainable Development, 2022 - 213.55.101.19
… review summarizes the development in synthetic methods of THβCs and their comprehensive
biological activities over the … The SAR studies have demonstrated that the introduction of …

Recent Progress for the Synthesis of β-Carboline Derivatives–an Update

V Patel, T Bambharoliya, D Shah, Y Patel… - Polycyclic Aromatic …, 2024 - Taylor & Francis
pharmacological potentialities and their derivatives have attracted a great deal of interest due
to their wide range of biological activities. β-… The studies reveal that the synthetic strategies

Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues

T Xu, L Shi, Y Zhang, K Wang, Z Yang, S Ke - European Journal of …, 2019 - Elsevier
… proven to exhibit diverse biological functions. During the course of our research for highly
active … were designed and synthesized, and their in vitro cytotoxic activities against SGC-7901, …

Synthesis, modeling, and RET protein kinase inhibitory activity of 3-and 4-substituted β-carbolin-1-ones

R Cincinelli, G Cassinelli, S Dallavalle… - Journal of medicinal …, 2008 - ACS Publications
… Among the different strategies developed to abrogate RET oncogenic activity, … SAR, it
appears that methylation of the indole nitrogen is not detrimental but seems to increase the activity (…

New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and StructureActivity Relationship

B Zhou, B Zhang, X Li, X Liu, H Li, D Li, Z Cui… - Scientific Reports, 2018 - nature.com
… been the leading strategy for the development of AD drugs, … Current clinical therapeutic
strategy for mild-to-moderate AD … due to their diverse biological activities such as antimicrobial 33 …

Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds

R Singh, A Jaisingh, IK Maurya, DB Salunke - Bioorganic & Medicinal …, 2020 - Elsevier
… to synthesize cis- and trans diastereomers to understand the effect of specific stereochemistry
on the biological activity. … Further SAR investigation on this lead compound to improve the …

Discovery of β-carboline-(phenylsulfonyl) furoxan hybrids as potential anti-breast cancer agents

X Hu, X Gao, G Gao, Y Wang, H Cao, D Li… - Bioorganic & Medicinal …, 2021 - Elsevier
strategy, and their inhibitory activities … in the biological activities. Furthermore, the compounds
(11g–j, 12g–j and 13g–j) linked with alkanolamine presented more potent inhibitory activity