Recent developments on synthesis strategies, SAR studies and biological activities of β-Carboline derivatives–an update
… , we highlight the recent developments and studies related to the design and synthesis of
β-… Furthermore, various derivatives of β-carboline with important biological activities which …
β-… Furthermore, various derivatives of β-carboline with important biological activities which …
β-Carboline alkaloid monomers and dimers: Occurrence, structural diversity, and biological activities
J Dai, W Dan, U Schneider, J Wang - European Journal of Medicinal …, 2018 - Elsevier
… activity relationship (SAR) and mechanism of their biological … In this section, highlighted
biological activities of β-carboline … development are discussed based on the structure−activity …
biological activities of β-carboline … development are discussed based on the structure−activity …
Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins
CH Yao, TC Hsieh, JS Song, JC Lee - Future Medicinal Chemistry, 2020 - Taylor & Francis
… studies of their biological activities have yet to be reported. … A solution of β-carbolin-1-one
thiohydantoin 5a (105 mg, 0.24 … , we studied their related structure–activity relationship by the …
thiohydantoin 5a (105 mg, 0.24 … , we studied their related structure–activity relationship by the …
Development in the Synthesis and Biological Activities of THβ-carboline and Its Analogs
N Bejigo, AM Yadessa - … of Science and Sustainable Development, 2022 - 213.55.101.19
… review summarizes the development in synthetic methods of THβCs and their comprehensive
biological activities over the … The SAR studies have demonstrated that the introduction of …
biological activities over the … The SAR studies have demonstrated that the introduction of …
Recent Progress for the Synthesis of β-Carboline Derivatives–an Update
… pharmacological potentialities and their derivatives have attracted a great deal of interest due
to their wide range of biological activities. β-… The studies reveal that the synthetic strategies …
to their wide range of biological activities. β-… The studies reveal that the synthetic strategies …
Synthesis and biological evaluation of marine alkaloid-oriented β-carboline analogues
T Xu, L Shi, Y Zhang, K Wang, Z Yang, S Ke - European Journal of …, 2019 - Elsevier
… proven to exhibit diverse biological functions. During the course of our research for highly
active … were designed and synthesized, and their in vitro cytotoxic activities against SGC-7901, …
active … were designed and synthesized, and their in vitro cytotoxic activities against SGC-7901, …
Synthesis, modeling, and RET protein kinase inhibitory activity of 3-and 4-substituted β-carbolin-1-ones
R Cincinelli, G Cassinelli, S Dallavalle… - Journal of medicinal …, 2008 - ACS Publications
… Among the different strategies developed to abrogate RET oncogenic activity, … SAR, it
appears that methylation of the indole nitrogen is not detrimental but seems to increase the activity (…
appears that methylation of the indole nitrogen is not detrimental but seems to increase the activity (…
New 2-Aryl-9-methyl-β-carbolinium salts as Potential Acetylcholinesterase Inhibitor agents: Synthesis, Bioactivity and Structure–Activity Relationship
B Zhou, B Zhang, X Li, X Liu, H Li, D Li, Z Cui… - Scientific Reports, 2018 - nature.com
… been the leading strategy for the development of AD drugs, … Current clinical therapeutic
strategy for mild-to-moderate AD … due to their diverse biological activities such as antimicrobial 33 …
strategy for mild-to-moderate AD … due to their diverse biological activities such as antimicrobial 33 …
Design, synthesis and bio-evaluation of C-1 alkylated tetrahydro-β-carboline derivatives as novel antifungal lead compounds
R Singh, A Jaisingh, IK Maurya, DB Salunke - Bioorganic & Medicinal …, 2020 - Elsevier
… to synthesize cis- and trans diastereomers to understand the effect of specific stereochemistry
on the biological activity. … Further SAR investigation on this lead compound to improve the …
on the biological activity. … Further SAR investigation on this lead compound to improve the …
Discovery of β-carboline-(phenylsulfonyl) furoxan hybrids as potential anti-breast cancer agents
X Hu, X Gao, G Gao, Y Wang, H Cao, D Li… - Bioorganic & Medicinal …, 2021 - Elsevier
… strategy, and their inhibitory activities … in the biological activities. Furthermore, the compounds
(11g–j, 12g–j and 13g–j) linked with alkanolamine presented more potent inhibitory activity …
(11g–j, 12g–j and 13g–j) linked with alkanolamine presented more potent inhibitory activity …