Reciprocal relationship between the tumor suppressors p53 and BAX in primary colorectal cancers

LA Simms, G Radford-Smith, KG Biden, R Buttenshaw… - Oncogene, 1998 - nature.com
… mutations were detected in MSI-high tumors. This study demonstrates that a reciprocal
relationship exists between p53 and BAX in sporadic colorectal cancers, and further supports the …

… on p53, BAX and Bcl-2 protein expression and microsatellite instability in stage III (UICC) colon cancer treated by adjuvant chemotherapy: major prognostic impact of …

O Nehls, T Okech, CJ Hsieh, T Enzinger… - … journal of cancer, 2007 - nature.com
… sporadic colorectal carcinoma, and it appears to be associated with different prognostic
features as compared with tumours harbouring microsatellite stable or low-frequency …

Resistance of colon cancer cells to long‐term 5‐fluorouracil exposure is correlated to the relative level of Bcl‐2 and Bcl‐XL in addition to Bax and p53 status

S Violette, L Poulain, E Dussaulx… - … journal of cancer, 2002 - Wiley Online Library
… been implicated in chemoresistance of colon cancer cells. We report … of 8 colon cancer cell
lines differing in p53 and bax status: … A reciprocal relationship has been reported between bax

Role of bax Mutations in Apoptosis in Colorectal Cancers With Microsatellite Instability

C Miquel, F Borrini, S Grandjouan… - American journal of …, 2005 - academic.oup.com
… In our series, there was no relationship between bax(G)8 mutations and p53 expression
or bcl-2 expression. Compared with the MSS CRCs, the CRCs with MSI had a significantly …

Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas

M Krajewska, SF Moss, S Krajewski, KI Song, PR Holt… - Cancer Research, 1996 - AACR
… progression of colorectal cancers. When compared to that … (c-myc), tumor suppressor genes
(p53), cytolytic T cells, radiation… , Bax expression was more often elevated than decreased in …

Differential expression of Bcl‐2, Bcl‐XL and p53 in colorectal cancer

HS Han, YM Park, TS Hwang - Journal of gastroenterology and …, 2006 - Wiley Online Library
tumor suppressor genes may play a role in the initiation and progression of colorectal
cancers… (eg Bax, Bak, Bad and Bcl-Xs) and downstream proteins of p53 (eg p21), the results …

Evidence for reciprocity of bcl-2 and p53 expression in human colorectal adenomas and carcinomas

AJM Watson, AJ Merritt, LS Jones, JN Askew… - … journal of cancer, 1996 - nature.com
Tumour suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.
… expression in colorectal carcinoma: correlation with tumour stage and patient survival. Br. J…

Genes mediating programmed cell death: an immunohistochemical study of bcl-2, c-myc and p53 expression in colorectal neoplasia

N Scott, I Martin, AS Jack, MF Dixon… - Clinical Molecular …, 1996 - ncbi.nlm.nih.gov
… vivo evidence of oncogene cooperation and reciprocity of p53/bcl-… Tumour suppressor
p53 is a regulator of bcl-2 and bax gene … of p53 and 17p allelic loss in colorectal carcinoma. …

… analysis of p53, BAX and vascular endothelial growth factor expression in node-positive rectal cancer. Relationships with tumour recurrence and event-free survival of …

S Cascinu, F Graziano, V Catalano, MP Staccioli… - … journal of cancer, 2002 - nature.com
… In the present study, BAX and p53 expressions did not show any association and only p53
… The predictive value of p53 is supported by experimental data which showed functional …

Genetic dissimilarity between primary colorectal carcinomas and their lymph node metastases: ploidy, p53, bcl-2, and c-myc expression—a pilot study

KR Zalata, MF Elshal, AARM Foda, A Shoma - Tumor Biology, 2015 - Springer
… One of these roles is the reciprocal relationship between bcl-… of proto-oncogenes and the
inactivation of tumor suppressor … Thirty-six cases with LN metastases of colorectal carcinoma