Regulation of apoptotic signaling pathways by -dihydrotestosterone and 17β-estradiol in immature rat Sertoli cells

VL Simoes, MG Alves, AD Martins, TR Dias… - The Journal of steroid …, 2013 - Elsevier
… of 17β-estradiol (E2) and -dihydrotestosterone (DHT) on the apoptotic signaling pathways
of immature rat … For that we chose key points of the apoptotic pathway that interact with the …

Molecular Mechanisms Elicited by d-Aspartate in Leydig Cells and Spermatogonia

MM Di Fiore, A Santillo, S Falvo, S Longobardi… - International Journal of …, 2016 - mdpi.com
… has been detected in Leydig cells, Sertoli cells and germ cells, notably in spermatogonia, …
is converted into -dihydrotestosterone by 5α-reductase (SRD5A1), or into 17β-estradiol by …

Estrogen receptor β selective ligand 5α-androstane-3β, 17β-diol stimulates spermatogonial deoxyribonucleic acid synthesis in rat seminiferous epithelium in vitro

A Wahlgren, K Svechnikov, ML Strand… - …, 2008 - academic.oup.com
… intermediate potent androgen -dihydrotestosterone (DHT), … Here, we have characterized
the influence of 17β-estradiol (E… ERβ, on the other hand, has been localized to rat Sertoli cells

The molecular mechanism of sex hormones on Sertoli cell development and proliferation

W Shah, R Khan, B Shah, A Khan, S Dil… - Frontiers in …, 2021 - frontiersin.org
… and testosterone signaling pathways in Sertoli cell proliferation… process, for example -dihydrotestosterone
(DHT) regulates … cell cycle arrest by interacting with 17β-estradiol (E2) (106). …

Estradiol Acts as a Germ Cell Survival Factor in the Human Testis in Vitro

V Pentikäinen, K Erkkilä… - The Journal of …, 2000 - academic.oup.com
… site from Sertoli cells in the immature testis to Leydig cells in … , and as this apoptosis can be
blocked by 17β-estradiol, we … a novel nongenomic signaling pathway through ERs located …

Follicle-stimulating hormone signaling in Sertoli cells: a licence to the early stages of spermatogenesis

JM Wang, ZF Li, WX Yang, FQ Tan - Reproductive Biology and …, 2022 - Springer
… The cAMP/PKA signaling pathway participates in Sertoli cell differentiation, SSC self-renewal …
in immature rat SCs activates the caspase 9 mediated intrinsic apoptotic pathway [118]. …

Estrogens and regucalcin in testicular apoptosis and sperm function:“a matter of life and death".

SCL Correia - 2014 - ubibliorum.ubi.pt
… A 100 nM dose of 17βestradiol (E2), mimicking the elevated … Signaling pathways implicated
in the estrogenic regulation of … by a single type of somatic cell, the Sertoli cell (SC). SSCs …

Estrogens and Regucalcin in Testicular Apoptosis and Sperm Function:" A Matter of Life and Death"

SC de Lima Correia - 2014 - search.proquest.com
… A 100 nM dose of 17βestradiol (E2), mimicking the elevated … Signaling pathways implicated
in the estrogenic regulation of … by a single type of somatic cell, the Sertoli cell (SC). SSCs …

[HTML][HTML] Estrogenic regulation of testicular expression of stem cell factor and c-kit: implications in germ cell survival and male fertility

S Correia, MR Alves, JE Cavaco, PF Oliveira… - Fertility and sterility, 2014 - Elsevier
… thus to male infertility because increased levels of 17β-estradiol (E 2 ) have been detected
… on isolated Sertoli cells that showed that 100 nM of E 2 diminishes Sertoli cells apoptosis by …

Dimethylbisphenol A inhibits the differentiation of stem Leydig cells in adult male rats by androgen receptor (NR3C4) antagonism

L Shi, J Li, F Tian, Y Tang, S Wang, Q Li, Y Zhu, Q Zhu… - Toxicology Letters, 2022 - Elsevier
… , Sod2, Cat, and Gpx1), apoptosis-related genes (Bcl2 and Bax), … regulated NR3C4 expression
in Sertoli cells and immature … Leydig cell maturation, other signaling pathways may be …