Repurposing bioactive aporphine alkaloids as efflux pump inhibitors

FG Avci, B Atas, CS Aksoy, E Kurpejovic, GG Toplan… - Fitoterapia, 2019 - Elsevier
… wide range of bioactivities they may inhibit efflux pumps. The current work repurposed the
bioactive alkaloid roemerine as a potential efflux pump inhibitor. In Bacillus subtilis, both Bmr …

[HTML][HTML] Naturally-occurring alkaloids of plant origin as potential antimicrobials against antibiotic-resistant infections

B Casciaro, L Mangiardi, F Cappiello, I Romeo… - Molecules, 2020 - mdpi.com
… most important sources of bioactive carbazole alkaloids [70,71… to further develop potent
inhibitors of these efflux pumps [73]. … Roemerine (Table 4) is an aporphine alkaloid isolated from …

[HTML][HTML] Advances in the Discovery of Efflux Pump Inhibitors as Novel Potentiators to Control Antimicrobial-Resistant Pathogens

S Zhang, J Wang, J Ahn - Antibiotics, 2023 - mdpi.com
… the inhibition of efflux pumps by alkaloids without illuminating the precise mechanisms
involved. … As a crucial source of bioactive molecules, natural plants have great promise for the …

Biological Importance and Therapeutic Effectiveness of Thaliporphine in Medicine: An Aporphine Alkaloid from Naturatl Sources

K Patel, DK Patel - Pharmacological Research-Natural Products, 2024 - Elsevier
Aporphine alkaloids are a class of natural products which is … , an aporphine alkaloid, is
one of the prominent bioactive … 1), an aporphine alkaloid, is one of the prominent bioactive

[HTML][HTML] Natural aporphine alkaloids with potential to impact metabolic syndrome

FX Wang, N Zhu, F Zhou, DX Lin - Molecules, 2021 - mdpi.com
… the activities of bioactive aporphine alkaloids: thaliporphine, … of actions by aporphine
alkaloids in metabolic syndrome. … Conjugation of roemerine to the substrate of efflux pump may …

Alkaloids: Their relevance in cancer treatment

C Varela, F Silva, G Costa, C Cabral - New Insights Into Glioblastoma, 2023 - Elsevier
… Stevensine is a bio-active bromopyrrole alkaloid that is … may be exported through efflux
pumps. Actually, uptake and … This drug repurpose will help to collect information about targeting …

Evaluation of silibinin as an efflux pump inhibitor in Bacillus subtilis

F Altınışık, B Ataş, FG Avcı - International Journal of Secondary …, 2021 - dergipark.org.tr
… of efflux pump inhibitors (EPIs) to interfere with efflux is one … the efflux of norfloxacin through
the NorA efflux pump protein in … of silibinin to inhibit the efflux pumps of Bacillus subtilis was …

Phytochemistry, history, and progress in drug discovery

D Sinha, UE Odoh, S Ganguly, M Muhammad… - … Tools and Databases in …, 2023 - Elsevier
… from plants that contain bioactive compounds which are … new natural phytochemicals and
to repurpose currently available, … , can inhibit the efflux pump activity of Campylobacter jejuni’s …

[PDF][PDF] 7th Postgradual and 5th Postdoctoral Scientific Conference of the Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, 7‒8 February …

OF DIABETES - Folia Pharm. Univ. Carol. XLVIII Pag, 2017 - karolinum.cz
… As the result of so called drug repurposing (using existing drugs in new indications) the …
UV (PDA) detector for analysis of biologically active substances with low or no response in UV …

[HTML][HTML] Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants

W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
… of bioactive antimicrobial candidates’ discovery. This review aims to focus on terpenoid,
alkaloid, and … Most alkaloids act as efflux pump inhibitors (EPIs) to exert antimicrobial effects—for …