… apply rQbD to achieve a greater understanding of the manufacturing process of ODFs and
to define a proper design … application of QbD principles using retrospective data (rQbD) and …

… Under the guidance of the QbD concept, this … was used to detect and analyze the crystalline
state of granisetron hydrochloride, excipients, physical mixture, blank film, and optimized film…

… orodispersible films was investigated and optimized using retrospective Quality by Design
(rQbD… In particular, the root-cause of a decrease in the drug release rate of orodispersible films …

… fast dissolving buccal film of clonidine hydrochloride by employing quality by … optimization
of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design,…

… The present research reveals the effectiveness of quality by design methodology to
optimize the formulation variables for the development of DXM and VAR oro-dispersible films. …

… to optimize and validate the manufacturing process of an existing commercial product by
means of a DoE with retrospective … by a retrospective factorial design with data of 36 batches. …

… as the development of Retrospective QbD approaches (rQbD) in complement to standard …
publishes about product development or optimisation focusing more on manufacturing and …

… parameters affected the quality of the coated tablets. The aim of this study is to detect critical
process parameters retrospectively and to … to the optimization of orodispersible films. Int. J. …

… introduction of Quality-by-Design (QbD) concepts that pharmaceutical product quality should
be … The aim of this study was the development, evaluation, and optimization of a CBD-ODT …

… The present study adopted a Quality by Design (QbD) … Design was used to systematically
evaluate the effects of inlet temperature, aspiration rate, and feed rate on the critical quality …