… Rofecoxib at therapeutic doses of 25 mg perday increased more … did not affect the kinetics
of caffeine and tizanidine [206]. … : studies with tizanidine and caffeine in healthy subjects. Br. J…

… The cytochrome P450 enzyme CYP1A2 primarily … In an open-label study of tizanidine (4
mg daily), 53.8% of patients with … , rofecoxib, rifampicin and recreational smoking Citation[66-69]. …

… design of selective P450 1A2 inhibitors as well as to study this enzyme’s active site cavity. …
) of caffeine in healthy volunteers [58]. Furafylline is a potent inhibitor of P450 1A2 phenacetin …

… (PK) trials, off-label use, and data on healthy volunteers further … that tizanidine is mainly
metabolized by cytochrome P450 … and rofecoxib have a major effect on tizanidine kinetics, …

… In this study, caffeine, tizanidine, and phenacetin were selected as typical CYP1A2 substrates.
First, the CV of CL int,h of CYP1A2 substrates was estimated from the AUC/Dose (AUC/D) …

… of cytochrome P450, which metabolizes 95% of the caffeine … In healthy humans, caffeine
is apparently eliminated via first-… of the research available is concentrated on caffeine and, to …

… ciprofloxacin (a CYP1A2 inhibitor) and tizanidine (a CYP1A2 … in this study included
acetaminophen, amitriptyline, caffeine, … model using 5 potent inhibitors of CYP1A2 and validated it …

… drugs, namely, caffeine and tacrine. In conclusion, pinocembrin has a … Rofecoxib
increased the plasma concentration of the CYP1A2 substrate tizanidine by 13.6-fold in humans…

… is also crucial for its elimination but the cytochrome P450 (CYP) enzymes … in healthy
volunteers, and (3) correlate tizanidine … effects of tizanidine were measured and a caffeine test, for …

… , it was observed that the subjects in this study were associated with … ) Rofecoxib is a potent
inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. Br …