… of drug-metabolizing enzymes (DMEs), particularly cytochromes P450 … were calculated in
the present study for the victim drugs … Because of its potent enzyme induction, RIF caused large …

… The purpose of this study was to investigate the extent of appropriate information being …
Caffeine may increase rate of bone loss in postmenopausal women. High doses of caffeine are …

… during nitric oxide synthase inhibition in humans. Am J Physiol Heart Circ … Rofecoxib is a
potent inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects…

… in humans; molecular biology and enzymology studies have … oxidases primarily involving
hepatic cytochromes P450 (CYPs) … leeks were the most potent inhibitors of both SULT1A1 and …

… metabolite, N3-demethylation of caffeine to paraxanthine, and O… In vitro studies included
incubating human hepatic … , is a potent inhibitor of CYP2A6 [2]. There is only one CYP2B …

… study revealed that the thenar motor units in the individuals … Tizanidine is metabolized in
the liver by cytochrome P450 … 1A2 inhibitors (including ciprofloxacin, fluvoxamine, rofecoxib, …

… effect of tizanidine by inhibiting its cytochrome P450 1A2mediated … Rofecoxib is a potent
inhibitor of cytochrome P450 1A2: studies with tizanidine and caffeine in healthy subjects. Br J …

… altered by co-administered silymarin in healthy volunteers. … Shear, 1997); and tizanidine is
a centrally acting α2 adrenergic … the caffeine N 3-demethylation breath test in individuals with …

… Ciprofloxacin is a potent inhibitor of CYP1A2 and a weak inhibitor of CYP3A4 4,5 . Some
studies … The animals used in this study were housed in a temperature- and humidity-controlled …

… The study of enzyme inhibition is still a popular topic in … total cytochrome P450 (CYP)
concentration in the liver. Phenacetin, tizanidine, theophylline, clozapine, zolmitriptan, and caffeine …