Effects of capsazepine against capsaicin-and proton-evoked excitation of single airway C-fibres and vagus nerve from the guinea-pig

AJ Fox, L Urban, PJ Barnes, A Dray - Neuroscience, 1995 - Elsevier
… In conclusion, we have shown that capsazepine is a specific antagonist of capsaicin and proton
activation … , evidence for a spinal receptor site in capsaicin-induced antinociception. Br. J. …

TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications

VD Marzo, K Starowicz, L Cristino - Current pharmaceutical …, 2008 - ingentaconnect.com
… suggested that capsaicin produces antinociception by … our aforementioned data on
capsaicin-induced glutamate release in … with capsazepine but not with the CB1 receptor

Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord

V Morisset, L Urban - Journal of neurophysiology, 2001 - journals.physiology.org
sites of antinociceptive action is the dorsal horn of the spinalevidence for direct spinal action
of cannabinoids in the … The attenuation of the capsaicin-induced increase in excitability and …

Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes

MD Southall, T Li, LS Gharibova, Y Pei, GD Nicol… - … of Pharmacology and …, 2003 - ASPET
… nervous system, recent evidence suggests a functional VR1 is … receptor antagonist capsazepine
abolished the capsaicin-… Our results indicate that the capsaicin-induced expression of …

Direct interaction of adenosine with the TRPV1 channel protein

P Puntambekar, J Van Buren… - Journal of …, 2004 - Soc Neuroscience
Capsaicin-induced inward currents in DRG neurons were … , such as capsaicin (100 μm), RTX
(1 μm), and capsazepine (10 … underlying the peripheral antinociceptive action of adenosine. …

Pronociceptive response elicited by TRPA1 receptor activation in mice

EL Andrade, AP Luiz, J Ferreira, JB Calixto - Neuroscience, 2008 - Elsevier
… SB 366791 (1 nmol/paw) only attenuated capsaicin-induced … might possess a potential
antinociceptive property. … with the non-selective TRPV1 antagonist capsazepine or with the …

Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative

GM Gonçalves, JM Oliveira… - Clinical and …, 2022 - Wiley Online Library
… in animals injected with capsaicin and capsaicin-induced nociception tests. … with capsazepine
and LS19 (300 µmol/kg). Intraplantar … Some evidence suggests that interference with motor …

Moving towards supraspinal TRPV1 receptors for chronic pain relief

E Palazzo, L Luongo, V de Novellis, L Berrino… - Molecular …, 2010 - journals.sagepub.com
… conditions provides morphological evidence that the sensitivity of … studies using capsazepine,
the prototype TRPV1 antagonist, … We proposed that capsaicin-induced antinociception was …

Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist

MJ Gunthorpe, HK Rami, JC Jerman, D Smart… - …, 2004 - Elsevier
… ; however, antagonists such as capsazepine are somewhat … that produced antagonism of
capsaicin-induced increases in … of evidence to support the occurrence of functional TRPV1 …

… involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of …

N Paulino, V Cechinel Filho, MG Pizzolatti… - … : The Vascular System, 1996 - Elsevier
Capsazepine (capsaicin antagonist, 3 μM) antagonized the … channel antagonist coupled to
vanilloid receptors of capsaicin… inhibition of HE- and capsaicin-induced contractions, but had …