Combination chemotherapy and photodynamic therapy with Fab′ fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells
J Hongrapipat, P Kopecková, J Liu… - Molecular …, 2008 - ACS Publications
… that enter cells by diffusion through the plasma membrane, … Studies on the subcellular fate
of HPMA copolymer−drug … the localization of a considerable fraction of HPMA copolymer−Mce …
of HPMA copolymer−drug … the localization of a considerable fraction of HPMA copolymer−Mce …
Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation
KA Boyle, J Van Wickle, RB Hill, A Marchese… - Journal of Biological …, 2018 - ASBMB
… more negative membrane potential of cancer cell mitochondria as an … , energy sensor signaling,
and functional effects on cancer cell … that drugs selectively targeting mitochondria induce …
and functional effects on cancer cell … that drugs selectively targeting mitochondria induce …
Molecular platforms for targeted drug delivery
… can also be achieved via the direct functionalization of the … -specific interactions with biological
membranes or other body … HPMA copolymers offer high drug loading capacity due to the …
membranes or other body … HPMA copolymers offer high drug loading capacity due to the …
Overcoming the barrier of CD8+ T cells: Two types of nano-sized carriers for siRNA transport
I Tabujew, M Willig, N Leber, C Freidel, I Negwer… - Acta Biomaterialia, 2019 - Elsevier
… functionality of the (HPMA-s-APMA)-b-GPMA block copolymer was cleaved to a free …
functionalization of cationic diblock copolymers with the uptake-promoting triphenylphosphonium …
functionalization of cationic diblock copolymers with the uptake-promoting triphenylphosphonium …
Fast and effective mitochondrial delivery of ω-Rhodamine-B-polysulfobetaine-PEG copolymers
N Morimoto, R Takei, M Wakamura, Y Oishi… - Scientific Reports, 2018 - nature.com
… polymers cross the cell membrane foremost by translocation and … positive charge, such as
triphenyl phosphonium (TPP) or … )methacrylamide (HPMA) as drug carriers 24 . We reported …
triphenyl phosphonium (TPP) or … )methacrylamide (HPMA) as drug carriers 24 . We reported …
A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy
… mitochondria-targeted drug delivery, a variety of nanoparticles decorated with targeting ligands
[22] including triphenylphosphonium (TPP) … The mitochondrial membrane potential was …
[22] including triphenylphosphonium (TPP) … The mitochondrial membrane potential was …
Peptides and drug delivery
KR Ulapane, BM Kopec, MEG Moral… - Peptides and peptide …, 2017 - Springer
… peptide’s N- or C-termini, or a side-chain functional group of … signal (NLS) and the lipophilic
triphenylphosphonium (TPP) … directed HPMA-KLA conjugates to the mitochondria with …
triphenylphosphonium (TPP) … directed HPMA-KLA conjugates to the mitochondria with …
Funtionalization of Pharmaceutical Nanocarriers for Mitochondria-Targeted Drug and DNA Delivery
V Weissig, S Boddapati, G D'Souza… - … Pharmaceutical …, 2008 - Springer
… nano drug carriers for mitochondrial-targeted drug and DNA … components of the mitochondrial
membrane and–depending on … triphenylphosphonium-bearing liposomes for mitochondria-…
membrane and–depending on … triphenylphosphonium-bearing liposomes for mitochondria-…
Strategies in the design of nanoparticles for therapeutic applications
RA Petros, JM DeSimone - Nature reviews Drug discovery, 2010 - nature.com
… They can also be functionalized, for example, with ligands to … the field of advanced drug
delivery based on nanotechnology… as triphenylphosphonium cations, to the surface of the carrier …
delivery based on nanotechnology… as triphenylphosphonium cations, to the surface of the carrier …