Mass transport via cellular barriers and endocytosis

S Ferrati, AK Streiff, S Srinivasan, JF Alexander… - Intracellular Delivery …, 2011 - Springer
… This chapter describes the journey of drug delivery from the site of … triphenylphosphonium
have shown effective delivery of a … This functionalization allows the nanoparticles to penetrate …

Dye-labelled polymer chains at specific sites: Synthesis by living/controlled polymerization

M Beija, MT Charreyre, JMG Martinho - Progress in polymer science, 2011 - Elsevier
… only one precisely localized dye per polymer … copolymers and end-functionalized (co)polymers)
with unprecedented properties for multiple applications. Therefore, end-functionalized (…

Antitumor activity and antitumor mechanism of triphenylphosphonium chitosan against liver carcinoma

H Huang, H Wu, Y Huang, S Zhang… - Journal of Materials …, 2018 - cambridge.org
… reported that BODIPY FL-labeled semitelechelic HPMA (N-(2-… organelle localization in the
isolated mouse liver mitochondria… did not disrupt the mitochondrial membrane integrity but just …

[PDF][PDF] Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin

M AbuEid, RF Keyes, D McAllister, F Peterson… - Iscience, 2022 - cell.com
… SUMMARY Triphenylphosphonium (TPP+) conjugated … by exploiting their hyperpolarized
mitochondrial membrane potential. To date… mitochondrial localization from functional effects on …

Novel IL-2-Poly (HPMA) nanoconjugate based immunotherapy

P Votavova, J Tomala, V Subr… - Journal of …, 2015 - ingentaconnect.com
… conjugated synthetic semitelechelic polymeric carrier based … field of polymer-based drug
delivery, although the situation … IL-2-poly(HPMA) conjugate are also functional in terms of rapid …

[图书][B] Copolymer construct to attenuate mechanotransduction and enhance lung capillary barrier function

KM Giantsos - 2011 - search.proquest.com
HPMA copolymers bearing triphenylphosphonium cationic … anti-inflammatory drug delivery
(59). Eselectin is chosen for … ammonium functional groups as opposed to copolymers

Intracellular delivery of polymeric nanocarriers: a matter of size, shape, charge, elasticity and surface composition

R Agarwal, K Roy - Therapeutic delivery, 2013 - Future Science
… Recent progress in drug discovery has enabled the targeting of … Therefore, it is imperative
that drug carriers are efficiently … in delivering drug across the cell membrane once they reach …

Can QSAR models describing small-molecule xenobiotics give useful tips for predicting uptake and localization of nanoparticles in living cells? And if not, why not?

RW Horobin - Organelle-specific pharmaceutical …, 2010 - books.google.com
… solve pressing problems of drug delivery and toxicology. However, we will … Semitelechelic,
HPMA copolymers functionalized with triphenylphosphonium as drug carries for membrane

Combination of Chlorambucil and Mercaptopurine Show Effective Anti-Cancer Effects in Mice Model

W Xu, Y Di, S Chu, Z Wang, H Long, L Pu… - International Journal …, 2023 - Taylor & Francis
… The introduction of HPMA as a carrier not only enhanced the … drug delivery but also provides
a feasible template for the co-… ability of PI to permeate the cell membrane. The HepG2 cells, …

Mitochondria and drugs

R Scatena - Advances in mitochondrial medicine, 2012 - Springer
… the inner mitochondrial membrane is critical for mitochondrial … for the selective targeting of
drugs to mitochondria to modulate … its functional role as an organelle, mitochondria represent, …