The Acute Complications Associated with the Use of Insulin Infusion Pumps

RS Mecklenburg - The Endocrinologist, 1991 - journals.lww.com
… Insulins containing m-cresol as a preservative have been associated … Some patients have
cutaneous sensitivity to the metallic … The issue of skin sensitivity to components of the infusion …

Immediate-type allergy against human insulin associated with marked eosinophilia in type 2 diabetic patient

Y NAGAI, T MORI, T ABE, G NOMURA - Endocrine journal, 2001 - jstage.jst.go.jp
… anaphylactic reactions. Thus, the insulin allergy of our case may have been a local dermal
… suspension and preservative agents such as paraben, cresol, and phenol). However, local …

Biologics: Monoclonal Antibodies for Non-cancer Therapy, Cytokines, Fusion Proteins, Enzymes, and Hormones

BA Baldo, NH Pham, BA Baldo, NH Pham - Drug Allergy: Clinical Aspects …, 2021 - Springer
… half-life and susceptibility to proteolysis due to its extended hinge … the presence of negative
skin tests to the glycoprotein, and acute … following skin breakdown due to the insulin excipient …

3PC-026 Effectiveness and safety of insulin 1UI/mL eye drops

CA Fernandez, MPB Sanz, AM Ortuño, EM Garcia… - 2023 - ejhp.bmj.com
… placed in a syringe for an easier application in the skin. It was given 30 days of stability at …
None hypersensitivity reaction were reported because of m-cresol presence in insulin eye …

[HTML][HTML] Type 1 Ig-E mediated allergy to human insulin, insulin analogues and beta-lactam antibiotics

P Andrade, L Barros, M Gonçalo - Anais brasileiros de dermatologia, 2012 - SciELO Brasil
… for an unspecific cutaneous reaction after intramuscular … oral therapy alone and intolerance
to some oral antidiabetics… as meta-cresol, zinc or protamine, included in commercial insulin

Enhancing thermal stability of a highly concentrated insulin formulation with Pluronic F-127 for long-term use in microfabricated implantable devices

J Li, MK Chu, B Lu, S Mirzaie, K Chen… - Drug delivery and …, 2017 - Springer
… is a major challenge due to increased susceptibility to aggregation … meta-cresol is also able
to increase stability of native insulin; … from severe hypoglycemia. To evaluate the bioactivity of …

Effects of PEG conjugation on insulin properties

KD Hinds, SW Kim - Advanced drug delivery reviews, 2002 - Elsevier
… or local-skin reactions whether in direct skin tests or in passive … relative to insulin, thus
decreasing their susceptibility to renal … can lead to more serious complications if left unchecked. …

Insulin, glucagon and hypoglycemic drugs

HMJ Krans - Side Effects of Drugs Annual, 1989 - Elsevier
… of large local reactions showed negative skin tests when … The 11 patients with positive
reactions were sensitive to both … such preservatives as m-cresol or from the diffusion of carbon …

[HTML][HTML] Two cases of allergy to insulin in gestational diabetes

GJ Kim, SB Kim, SI Jo, JK Shin, HS Kwon… - Endocrinology and …, 2015 - ncbi.nlm.nih.gov
reactions range from local injection site reactions to severe … We suspected insulin
hypersensitivity and performed skin … and the increased susceptibility to influenza infections during …

[PDF][PDF] Allergic

SS contact DermatitiS - dermatitisacademy.com
… provoke severe skin reactions.Although allergic reactions to subcutaneously injected insulin
… Severe adverse cutaneous reaction to insulin due to cresol sensitivity. Contact Dermatitis. …