Targeting EGFR and VEGF (R) pathway cross-talk in tumor survival and angiogenesis

AK Larsen, D Ouaret, K El Ouadrani… - Pharmacology & …, 2011 - Elsevier
… (NRPs) thereby triggering signal transduction cascades that promote endothelial cell (EC) …
been carried out in patients with metastatic colorectal cancer. A randomized study in CRC …

[HTML][HTML] PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
… The PAM axis is the most frequently activated signaling pathway in human cancer … in cancer.
In this review we highlight the major dysregulations in the PAM signaling pathway in cancer, …

Crosstalk between bile acids and gastrointestinal tract for progression and development of cancer and its therapeutic implications

S Kundu, S Kumar, A Bajaj - IUBMB life, 2015 - Wiley Online Library
signal transduction throughcross-talk between bile acids and p53 can help in prevention
of accumulation of mutations, and loss of these functions may result in induction of colon cancer

Advances in targeted and immunobased therapies for colorectal cancer in the genomic era

HF Seow, WK Yip, T Fifis - OncoTargets and therapy, 2016 - Taylor & Francis
… networks, and cross talk between pathways are … through engaging DR4 and/or DR5
expressed on the plasma membrane of target cancer cells, and triggers signal transduction

Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways

AS McElhinny, JL Li, L Wu - Oncogene, 2008 - nature.com
… Broadly speaking, cancer results from deregulation of the … environmental stimuli through
specific signaling transduction pathways. … for manipulating signaling pathways critical for cancer

[HTML][HTML] Inhibition of STAT5 induces G1 cell cycle arrest and reduces tumor cell invasion in human colorectal cancer cells

H Xiong, WY Su, QC Liang, ZG Zhang, HM Chen… - Laboratory …, 2009 - Elsevier
… /JNK in CRC cells, suggesting cross talk between STAT5 signaling and the MAPK pathway
in … mechanisms of CRC tumorigenesis, the specific signal transduction pathways involved in …

[HTML][HTML] PIK3CB and K-ras in oral squamous Cell carcinoma. A possible cross-talk!

NH Al-Rawi, MS Merza, AM Ghazi - Journal of Orofacial Sciences, 2014 - journals.lww.com
signal transduction have been identified. Ras genes are the most frequently mutated oncogenes
in human cancer… tyrosine kinases (like EGFR)in colorectal cancer, as well as by binding …

Protein crosstalk in CD 133+ colon cancer cells indicates activation of the W nt pathway and upregulation of SR p20 that is potentially involved in tumorigenicity

C Corbo, S Orrù, M Gemei, RD Noto, P Mirabelli… - …, 2012 - Wiley Online Library
… Finally, we demonstrate that SRp20 affects the expression of mutated in colorectal cancer
(… identified are closely related to the signal transduction pathway of the Wnt protoncogene. …

NF-κB pathways in the development and progression of colorectal cancer

M Patel, PG Horgan, DC McMillan, J Edwards - Translational Research, 2018 - Elsevier
… IL-6/STAT3 (signal transduction activator of transcription-3), 36 … linked signaling pathways
such as STAT3 in colon cancer … of NF-κB/p53 cross talk in colon cancer and, more recently, the …

[HTML][HTML] Cross talk between autophagy and oncogenic signaling pathways and implications for cancer therapy

S Zada, JS Hwang, M Ahmed, TH Lai, TM Pham… - … )-Reviews on Cancer, 2021 - Elsevier
… The PI3K/AKT/MTORC1 axis induced by growth factors is a major signal transduction
pathway in cancer cell growth in nutrient-rich conditions. Conversely, inhibition of this pathway …