Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis
… the current understanding of cross-talk between Wnt/β-catenin … The highlight of the cross-talk
is the stabilizations of both β-… KRAS mutations in colorectal tumorigenesis including initiation…
is the stabilizations of both β-… KRAS mutations in colorectal tumorigenesis including initiation…
mTOR cross-talk in cancer and potential for combination therapy
F Conciatori, L Ciuffreda, C Bazzichetto, I Falcone… - Cancers, 2018 - mdpi.com
… signaling, describe its cross-talk with other pathways, and examine its contribution to human
cancer … The AKT/mTOR signaling transduction pathway plays a central role in integrating …
cancer … The AKT/mTOR signaling transduction pathway plays a central role in integrating …
[HTML][HTML] Cross-Talk between the TGF-β and Cell Adhesion Signaling Pathways in Cancer
J Liao, R Chen, B Lin, R Deng, Y Liang… - … Journal of Medical …, 2024 - ncbi.nlm.nih.gov
… signal transduction. CAMs function as transmembrane proteins, the extracellular domain
stabilizes cells to bind to adjacent cells and ECM, while … the migration of colorectal cancer cells …
stabilizes cells to bind to adjacent cells and ECM, while … the migration of colorectal cancer cells …
Positive cross talk between protein kinase D and β-catenin in intestinal epithelial cells: impact on β-catenin nuclear localization and phosphorylation at Ser552
J Wang, L Han, J Sinnett-Smith… - … of Physiology-Cell …, 2016 - journals.physiology.org
… used as a model system to examine signal transduction pathways in response to GPCR
activation (… for the function of the pathway in normal and cancer cells is well recognized (22), the …
activation (… for the function of the pathway in normal and cancer cells is well recognized (22), the …
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
R Sancho, AS Nateri, AG De Vinuesa, C Aguilera… - The EMBO …, 2009 - embopress.org
… model of colorectal carcinogenesis. … signalling regulates intestinal homeostasis and
tumourigenesis, and we propose that this at least in part is due to a cross talk of JNK to Wnt signalling…
tumourigenesis, and we propose that this at least in part is due to a cross talk of JNK to Wnt signalling…
[HTML][HTML] Gankyrin sustains PI3K/GSK-3β/β-catenin signal activation and promotes colorectal cancer aggressiveness and progression
F He, H Chen, P Yang, Q Wu, T Zhang, C Wang, J Wei… - Oncotarget, 2016 - ncbi.nlm.nih.gov
… Importantly, we found a unique molecular mechanism of Gankyrin in CRC cells signaling
transduction, that regulated the cross-talk between PI3K/Akt and Wnt/β-catenin signaling …
transduction, that regulated the cross-talk between PI3K/Akt and Wnt/β-catenin signaling …
The role of the tumor microenvironment in colorectal cancer and the potential therapeutic approaches
… cross talk between these cells may result in either advantages or disadvantages in tumor
development and metastasis, affecting the signals … Class 1 agents suppress signal transduction …
development and metastasis, affecting the signals … Class 1 agents suppress signal transduction …
Bcl-2 orchestrates a cross-talk between endothelial and tumor cells that promotes tumor growth
T Kaneko, Z Zhang, MG Mantellini, E Karl, B Zeitlin… - Cancer research, 2007 - AACR
… endothelial cells through a signal transducer and activator of … Endothelial cell–derived VEGF
signals through VEGFR1 and … metastatic colorectal cancer and non–small-cell lung cancer (…
signals through VEGFR1 and … metastatic colorectal cancer and non–small-cell lung cancer (…
Colon carcinogenesis: Learning from NF-κB and AP-1
AG Vaiopoulos, KK Papachroni… - The international journal …, 2010 - Elsevier
… Colorectal cancer (CRC) is among the most common types … mutations and abnormalities in
signal transduction pathways. Most … Growth factors (GFs) and cytokines mediate the cross-talk …
signal transduction pathways. Most … Growth factors (GFs) and cytokines mediate the cross-talk …
The Hippo pathway in colorectal cancer
PM Wierzbicki, A Rybarczyk - Folia histochemica et …, 2015 - journals.viamedica.pl
… of its major signal transducers were proposed as … cross talk between Hippo and EGFR/KRAS
signalling pathways since their interactions may be involved in drug resistance during CRC …
signalling pathways since their interactions may be involved in drug resistance during CRC …