… in cancer treatment by natural products are MAPK, PI3K/Akt, and NF- κB [4], [5]. Notably, it has
been observed that signal transducer … Breast cancer, colorectal cancer, gastric cancer, and …

… signaling cascades and accomplishments of the human WNT-ome project will be reviewed
in the first part of this article, and then cross-talk … (SMO) signal transducer from functional …

… our findings with colorectal cancer cells. The finding that Notch3 could be regulated through
a tumor-EC interaction suggests a novel function of angiogenesis in cancer, uncoupled from …

… (JAK2)-signal transducer and activator of transcription 3 and 5 (STAT3/5) signaling in both
p53-… -independent apoptosis of colon cancer cells. Whereas xenografts of p53-deficient colon …

… disease and colorectal cancer, and … cancer, and the utilization of the same signal transduction
pathways, as normal stem cells but different than those utilized by the differentiated cancer …

… Furthermore, we propose a mechanism for ANP action illustrating a possible cross-talk
between the NHE-1-dependent intracellular alkalinization of tumor cells and the Wnt signaling …

… cross-talk when predicting functional outcomes of signaling, … Cross-talk between these two
pathways may have differing … of β-catenin signaling is a key event in colorectal carcinogenesis …

… participate in intracellular signal transduction pathways, linking … Interestingly, a cross-talk
between integrins and cadherins … morphological differentiation of colorectal tumour cells in vitro.…

… cross talk between stromal CAFs and colorectal cancer cells. Currently, we revealed that in
human colon cancer … the interaction between CAFs and colon cancer cells. These findings …

… found in glioma tissue and facilitate gap-junction signal transmission (88, 90). In addition, …
Cholinergic stimulation also prevents colorectal cancer progression by inducing trefoil factor …