Drug repurposing in cancer

L Sleire, HE Førde, IA Netland, L Leiss, BS Skeie… - Pharmacological …, 2017 - Elsevier
… for patients above 40 years with increased risk cardiovascular disease and colorectal cancer
… chemotherapy did not have any survival benefit compared to patients not on digoxin [79]. …

[HTML][HTML] Antidepressant use and colorectal cancer morbidity and mortality: a dose-response meta analysis

L Chen, X Li, C Li, C Zou - Medicine, 2020 - journals.lww.com
survival rate of colorectal liver metastases patients after surgical resection is up to 50%, but
only 20% of patients … inhibitor (SNRI) and tricyclic antidepressant (TCA) treat depression. The …

Depression in glioma: a primer for clinicians and researchers

AG Rooney, PD Brown, JC Reijneveld… - Journal of Neurology …, 2014 - jnnp.bmj.com
… between tricyclic antidepressant (TCA) prescription and all-cause mortality following …
Survival of glioma and colorectal cancer patients using tricyclic antidepressants post-diagnosis

[HTML][HTML] Drug repositioning in glioblastoma: a pathway perspective

SK Tan, A Jermakowicz, AK Mookhtiar… - Frontiers in …, 2018 - frontiersin.org
treatment, which extends life in most cases. Unfortunately, tumor recurrence is nearly universal
and patients with recurrent glioblastoma typically survive <1 … approved for use in patients. …

Blind snipers: relevant off target effects of non-chemotherapeutic agents in oncology: review of the literature

T Prochilo, B Di Biasi, F Aroldi… - Reviews on recent …, 2014 - ingentaconnect.com
… aspirin in mutated-PIK3CA colorectal cancer patients was associated with better colorectal
Survival of glioma and colorectal cancer patients using tricyclic antidepressants postdiagnosis

[HTML][HTML] Pharmacological treatment of depression in people with a primary brain tumour

Z Beevers, S Hussain, FW Boele… - The Cochrane Database …, 2020 - ncbi.nlm.nih.gov
… of using tricyclic antidepressants for mortality reduction in people with glioma or colorectal
cancer. … , examining the relationship between depression and survival in glioma. However, the …

[HTML][HTML] Psychotropic drugs show anticancer activity by disrupting mitochondrial and lysosomal function

M Varalda, A Antona, V Bettio, K Roy… - … in oncology, 2020 - frontiersin.org
… in colorectal carcinoma, glioblastoma and breast cancer cell … restricted to colorectal cancer
and breast cancer and caused … tumors are highly dependent on autophagy for survival and …

[HTML][HTML] … reveals role of mitochondrial germ-line mutation F18L in respiratory chain, oxidative alterations, drug sensitivity, and patient prognosis in glioblastoma

K Keatley, S Stromei-Cleroux, T Wiltshire… - International journal of …, 2019 - mdpi.com
survival for glioblastoma patients well enough to receive the standard of care treatment is just
14.6 months post-diagnosis … Clomipramine is a tricyclic antidepressant drug that is effective …

[HTML][HTML] A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer

EE Rabin, M Kim, A Mozny, K Cardoza, AC Bell… - Brain, Behavior, & …, 2022 - Elsevier
… , 2 publications included serotonin and norepinephrine reuptake inhibitors (SNRIs), 5
publications included tricyclic antidepressants (TCAs), and 7 publications included other atypical …

Review of pharmacological treatment of depression in patients with primary brain tumour and proposal of modification in management strategy

OK Onyia, CU Onyia - Clinical Neurology and Neurosurgery, 2022 - Elsevier
… worsen overall survival and prognosis in patients with brain … inhibitors (SSRIs), the tricyclic
antidepressants (TCA) and the … of using TCAs for patients with glioma or colorectal cancer. …