Recent advances toward development of plant cell culture process for sustainable production of lignans and their health benefits

AMM Gabr, HB Mabrok, O Sytar… - Exploring plant cells for the …, 2021 - Springer
… The aim of this review is to focus on lignans: biosynthesis in … its high content of
secoisolariciresinol diglucoside (SDG) and … , phenolic acids, and antioxidant capacity in …

Anticancer potential of flaxseed lignans, their metabolites and synthetic counterparts in relation with molecular targets: current challenges and future perspectives

A Mueed, Z Deng, SA Korma, S Shibli, M Jahangir - Food & Function, 2023 - pubs.rsc.org
… of secoisolariciresinol diglucoside (SDG) which can be metabolised by the gut microbes into
secoisolariciresinol (… to be linked with the strong antioxidant activity of the lignans present. …

[PDF][PDF] Phase I and II enzyme induction and inhibition by secoisolariciresinol diglucoside and it's aglycone

EMR Boyd - 2007 - harvest.usask.ca
… Figure 4.2: The effect of increasing Secoisolariciresinol (SECO) concentration and …
Figure 4.3: The effect of increasing Secoisolariciresinol Diglucoside (SDG) concentration and …

Phenolic compounds in flaxseed: a review of their properties and analytical methods. An overview of the last decade

…, H Trabelsi, I Bouali, S Boukhchina… - Journal of Oleo …, 2014 - jstage.jst.go.jp
… lignans reside in their antioxidant capacity. The antioxidant capacity of SDG is related to
the … SDG diglycoside and its aglycone, secoisolariciresinol display a very high antioxidant …

Isolation and characterization of flaxseed (Linum usitatissimum) constituents

SX Qiu, ZZ Lu, L Luyengi, SK Lee… - Pharmaceutical …, 1999 - Taylor & Francis
… center of secoisolariciresinol diglucoside (SDG, 6) was … of 1, were shown to mediate
antioxidant activity which may … In the case of flaxseed, secoisolariciresinol diglucoside (SDG) …

Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside

A Ayella, S Lim, Y Jiang, T Iwamoto, D Lin, J Tomich… - Nutrition research, 2010 - Elsevier
… glycoside precursors, such as secoisolariciresinol diglucoside (SDG), which have not been
evaluated yet. This study tested the hypothesis that dietary SDG might have a different effect …

[PDF][PDF] Comparative oral pharmacokinetics and efficacy of flaxseed lignan-purified SDG and SDG polymer

A Guo - 2020 - harvest.usask.ca
… lignan, mainly as secoisolariciresinol diglucoside (SDG), can … synthesis and absorption of
dietary and biliary cholesterol. … ) scavenging indicating that the antioxidative ability is greater …

Flaxseed lignan secoisolariciresinol diglucoside ameliorates experimental colitis induced by dextran sulphate sodium in mice

J Xu, G Tian, C Ma, H Gao, C Chen, W Yang… - Journal of functional …, 2016 - Elsevier
… The effect of flaxseed lignan secoisolariciresinol diglucoside (SDG) on ulcerative … of SDG
to act as a colon cancer preventative agent has been partly attributed to its strong antioxidant, …

Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development

A Ramsay, O Fliniaux, A Quéro, R Molinié, H Demailly… - Food chemistry, 2017 - Elsevier
… The main flax lignan, secoisolariciresinol diglucoside, is stored in a … its biosynthesis in
flaxseed. It is well established that … The SDG content of the flaxseeds was around 6.4 mg/g (…

Secoisolariciresinol diglucoside lignan concentrate of flaxseeds exhibits chemoprotective role in non-melanoma skin cancer through inhibition of CDK4 and …

YS Patel, BM Patel - Indian Journal of Experimental Biology (IJEB …, 2021 - op.niscpr.res.in
… of SDG lignan concentrate (SLC) of Linum usitatissimum (L.) on skin cancer are not available.
Hence, in this study, we evaluated … First-strand cDNA was synthesized from 1. 0 µg of RNA …