… properties of melanin, beginning with biosynthesis from ortho… to quinones, polymerize
spontaneously to melanin. It follows … holds that in Cryptococcus neoformans, an important function …

… After 21 days, infected mice were sacrificed and melanin ghosts were isolated from infected
… neoformans can synthesize melanin from a variety of substrates, we evaluated the porosity …

… We will particularly focus on Cryptococcus neoformans and … oxidized and polymerized to
produce DOPA melanin [8]. … Melanin synthesis needs to occur in a contained environment …

… due to the proximity of lipid membranes to the site of melanin polymerization. Purified …
Based on these data we propose a model for melanization in which melanin synthesis occurs in …

… and are formed by the oxidative polymerization of phenolic and/or … In the human fungal
pathogen Cryptococcus neoformans melanin is … Briefly, adult female BALB/c mice received five …

… , DOPA-melanin through the polymerization of dihydroxyindole (… Camacho are Cryptococcus
neoformans (top left) and C. … neoformans requires exogenous precursors for the synthesis …

… to form a ‘shell’ of polymerized melanin over this period of time. … of de novo synthesis of
melanin and capsule by buds of C. … melanin-binding mAbs prolong survival in mice infected with …

… One capsule synthesis model proposed envisions capsule biosynthesis … mice and show
numerous defects in melanin production, capsule formation, urease production or growth at 37 C…

… neoformans cells synthesize melanin during infection and that this … neoformans infections
in mice elicited brisk antibody … not sufficient to conclude that polymerized melanin of the type …

… the rat model of cryptococcosis have demonstrated that rats … by the oxidative polymerization
of phenolic compounds [80]. … Biosynthesis of major virulence factors, melanin and capsule …