Cryptococcus neoformans Virulence Is Enhanced after Growth in the Genetically Malleable Host Dictyostelium discoideum

JN Steenbergen, JD Nosanchuk… - Infection and …, 2003 - Am Soc Microbiol
… in myosin VII synthesis resulted in infection, validating the … capsule, the ability to make melanin
pigments, and the capacity to … resulting in actin polymerization and particle internalization …

Cryptococcus neoformans chitin synthase 3 plays a critical role in dampening host inflammatory responses

CR Hole, WC Lam, R Upadhya, JK Lodge - MBio, 2020 - Am Soc Microbiol
… , as mice inoculated with a heat-killed preparation of the chs3Δ strain died at the same rate as
mice inoculated … Chitin is polymerized from cytoplasmic pools of UDP-GlcNAc by a multiple …

[PDF][PDF] The Role of Melanin in Fungal Disease

RJB Cordero - Melanins: Functions, biotechnological production, and … - researchgate.net
… of fungal biosynthesis for the three most prevalent melanin … by the oxidation and subsequent
polymerization of HGA, an … Meanwhile, infections with Cryptococcus neoformans or C. …

The C. Neoformans Cell Wall: A Scaffold for Virulence

C Chrissian - 2020 - search.proquest.com
… all animal kingdoms and is also the type of melanin synthesized by C. … -DHN, which is
subsequently polymerized to become DHN melanin, the sole end … neoformans in infected rodents. …

Biosynthesis and Functions of Melanin inSporothrix schenckii

R Romero-Martinez, M Wheeler… - Infection and …, 2000 - Am Soc Microbiol
polymerization of DHN to form DHN melanin (3, 5, 33, 45). Another pathogen, like Cryptococcus
neoformans, produces melanin … from male BALB/c mice by washing the peritoneal …

Disarming Fungal Pathogens: Bacillus safensis Inhibits Virulence Factor Production and Biofilm Formation by Cryptococcus neoformans and Candida albicans

FL Mayer, JW Kronstad - MBio, 2017 - Am Soc Microbiol
melanin biosynthesis) and … mice reduced cryptococcal and candidal infection (76, 77).
Moreover, it was recently shown that chitotriosidase recognizes cryptococcal chitin during infection

Vaccines and Antibody Therapies from Cryptococcus neoformans to Melanoma

A Casadevall, E Dadachova… - Cryptococcus: from …, 2010 - Wiley Online Library
… have synthesized oligosaccharides representing cryptococcal … cell turnover and that such
melanin would be accessible to … melanin could be used to arrest tumor growth in nude mice

Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

W Sabiiti, E Robertson, MA Beale… - The Journal of …, 2014 - Am Soc Clin Investig
… of Cryptococcus neoformans with clinical outcome of infected patients… Laccase is a critical
enzyme for the synthesis of melanin, a … may be different from in vitro polymerization of L-DOPA. …

The role of melanins in melanotic fungi for pathogenesis and environmental survival

HC Eisenman, EM Greer, CW McGrail - Applied microbiology and …, 2020 - Springer
… We begin with a brief review of melanin synthesis and its … Polymerization of DHN leads to
formation of melanin. Many … Cryomyces antarcticus and Cryptococcus neoformans differ in …

Melanization of Cryptococcus neoformans reduces its susceptibility to the antimicrobial effects of silver nitrate

J Garcia-Rivera, A Casadevall - Sabouraudia, 2001 - academic.oup.com
… has a laccase enzyme that catalyzes the synthesis of melanin-like pigments from various …
could be potentiated by L-dopa polymerization intermediates. In our experimental conditions, …