Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond

A Lahiri, P Das, D Chakravortty - Vaccine, 2008 - Elsevier
… and CD70 in the antigen presenting cells and production of … synthetic TLR4 agonist, E6020
elicits an immunostimulatory … the development of antitumor T cell responses when used as …

[HTML][HTML] Endoplasmic reticulum-targeting sequence enhanced the cellular immunity of a tumor-associated antigen L6-based DNA vaccine

YP Sher, SI Lin, KM Chai, IH Chen… - American Journal of …, 2019 - ncbi.nlm.nih.gov
… that a synthetic peptide containing HLA-A2-restricted cytotoxic T … Notably, pEKL6 elicited
long-term anti-tumor immunity … I molecules on the surface of antigen-presenting cells (APCs) for …

CD137 and CD137L signals are main drivers of type 1, cell-mediated immune responses

B Dharmadhikari, M Wu, NS Abdullah… - …, 2016 - Taylor & Francis
… (CD137L) is expressed by antigen presenting cells (APC), … or anti-CD137L antibody elicits
different effects on acute … in turn inhibits immunoglobulin synthesis and reduces the disease …

Micro-and nanoparticulates for DNA vaccine delivery

E Farris, DM Brown, AE Ramer-Tait… - … biology and medicine, 2016 - journals.sagepub.com
… target DNA to professional antigen presenting cells. Finally, … provide protection to pDNA and
allow for controlled, cell-targeted… delivery systems, including synthetic and natural polymeric …

Eliciting epitope-specific cd8+ t cell response by immunization with microbial protein antigens formulated with α-galactosylceramide: theory, practice, and protocols

P Gilchuk, FC Knight, JT Wilson, S Joyce - Vaccine Adjuvants: Methods …, 2017 - Springer
… + T cell-targeted vaccines. Hence, harnessing a non-polymorphic antigen-presenting molecule
and invariant T cells … αGalCer is a synthetic glycolipid that closely resembles the marine …

[HTML][HTML] γδ T cell-mediated immune responses in disease and therapy

TS Latha, MC Reddy, PVR Durbaka… - Frontiers in …, 2014 - frontiersin.org
… γδ T cells show enhanced antigen-presenting cell (APC) … antigens and synthetic peptides
to CD4 + T cells and B cells thus … Further, clinical trials are required for the γδ T cell targeted

PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity

AL Silva, PC Soema, B Slütter… - Human vaccines & …, 2016 - Taylor & Francis
… recombinant protein- and synthetic peptide-based vaccine … ; can be targeted to antigen
presenting cells; and their particulate … to elicit an adaptive antigen-specific immune response and …

Mannose-modified PLGA nanoparticles for sustained and targeted delivery in hepatitis B virus immunoprophylaxis

J Zhu, F Qin, Z Ji, W Fei, Z Tan, Y Hu, C Zheng - AAPS PharmSciTech, 2020 - Springer
… Here, to target antigen-presenting cells under the epidermis … synergistic protective effect of
combined humoral and cellular … B vaccine through subcutaneously injection to elicit high-level …

[HTML][HTML] Immunogenicity of a tripartite cell penetrating peptide containing a MUC1 variable number of tandem repeat (VNTR) and AT helper epitope

N Brooks, J Hsu, S Esparon, D Pouniotis, GA Pietersz - Molecules, 2018 - mdpi.com
… to antigen presenting cells to induce cytotoxic T cell, helper T … OVA-specific immunity and
protection from tumour challenge in … synthetic peptides incorporating multiple CD8 and CD4 T

Multi-functional nanocomplex codelivery of Trp2 and R837 to activate melanoma-specific immunity

Z Ji, Z Tan, M Li, J Tao, E Guan, J Du, Y Hu - International Journal of …, 2020 - Elsevier
… of Trp2 and R837 into antigen-presenting cells (APCs). R837 … usually elicit weak and short-lived
immune responses owing … The inclusion of R837 in man-CD and synthesis of WT altered …