Engineered nanoparticles for cancer vaccination and immunotherapy

ME Aikins, C Xu, JJ Moon - Accounts of chemical research, 2020 - ACS Publications
… of tumor antigens as immune targets while exploiting … to lymph nodes, generating strong
antitumor T cell immunity. … able to elicit antitumor immunity against disseminated tumors…

[HTML][HTML] Nanoparticle drug delivery systems designed to improve cancer vaccines and immunotherapy

Y Fan, JJ Moon - Vaccines, 2015 - mdpi.com
… by targeting nanovaccines to tumor-draining lymph nodes … microbubbles to allow
ultrasound-triggered transfection of DCs. … designed to elicit anti-tumoral immune responses. In …

[HTML][HTML] Nanoparticle delivery of immunostimulatory agents for cancer immunotherapy

J Zhuang, M Holay, JH Park, RH Fang, J Zhang… - Theranostics, 2019 - ncbi.nlm.nih.gov
… promising means of elevating antitumor immunity. Here, we … of nanoparticles, thus enhancing
uptake efficiency by target … help to enhance nanoparticle localization in the lymph nodes, …

Nanoparticle‐based nanomedicines to promote cancer immunotherapy: recent advances and future directions

J Liu, R Zhang, ZP Xu - Small, 2019 - Wiley Online Library
… but significantly enhance the antitumor immunity. … in PLGA nanoparticles migrated to draining
lymph nodes and … The TDLNs-targeted nanoparticles increased the amount of cytokines IL-…

Nanotechnology-based approaches to promote lymph node targeted delivery of cancer vaccines

R He, J Zang, Y Zhao, H Dong, Y Li - ACS Biomaterials Science & …, 2022 - ACS Publications
… inhibits and eliminates cancer by activating the immune system. … vaccines to reactivate
antitumor immune response and … or chemical synthesis, achieve the specific targeting with locally …

[HTML][HTML] Biodegradable polymeric nanoparticles-based vaccine adjuvants for lymph nodes targeting

A Gutjahr, C Phelip, AL Coolen, C Monge, AS Boisgard… - Vaccines, 2016 - mdpi.com
… We point out how these nanoparticles enhance the delivery of … However, nanoparticles
seem to be able to trigger either … Synthetic vaccine particles co-encapsulating a model antigen …

Efficient nanovaccine delivery in cancer immunotherapy

G Zhu, F Zhang, Q Ni, G Niu, X Chen - ACS nano, 2017 - ACS Publications
… secondary lymphoid organs such as lymph nodes (LNs) and … induce optimal antitumor
immunity. Adjuvants induce robust … Nanovaccines have been developed for LN-targeted delivery …

Emerging advances in synthetic cancer nano-vaccines: opportunities and challenges

MZ Ahmad, J Ahmad, A Haque… - … review of vaccines, 2020 - Taylor & Francis
Nanoparticles (NPs) vaccine delivery … a better target to an effective immune response.
They can be quickly drained via lymphatic systems to lymph nodes, which is full of immune cells. …

Mannan-decorated pathogen-like polymeric nanoparticles as nanovaccine carriers for eliciting superior anticancer immunity

Y Xu, S Ma, J Zhao, H Chen, X Si, Z Huang, Z Yu… - Biomaterials, 2022 - Elsevier
… synergize with CpG for maximally activating the DCs. Excitingly… role in the lymph node drainage
of nanoparticles, with sizes … Besides, decorating particles with actively targeting moieties, …

Nanoparticles for tumor immunotherapy

X Zang, X Zhao, H Hu, M Qiao, Y Deng… - European Journal of …, 2017 - Elsevier
… However, antitumor immunity driven by self-immune system … to target DCs in lymphatic
nodes. They found that 20 nm … Likewise, nanoparticulate aAPCs aimed at directly activating T …