… Nanoparticles, microparticles, and other biomaterials are … , and targeting to alter the interactions
of cells, signals, and … Thus, triggering both of these pathways may enhance B cell (TLR4) …

… self-assembling nanoparticle platform markedly enhanced … (either in the same or in separate
nanoparticle preparations). We … by targeting their activity to the draining lymph node and …

… , but also potentially trigger stronger antitumor immune responses, … decades, nanotechnology
has been used to enhance the … targeting LNs to evoke a personalized antitumor immune …

… Targeting different receptors is able to interfere specific steps in immunogenicity and finally
… immunity at varied intensity. For instance, mannose receptor has been reported to trigger …

… peptide vaccines and enhanced therapeutic antitumor immunity… adjuvants in lymph nodes
(LNs) using nanoparticle carriers … with the latter suggesting systemic triggering of STING. Thus, …

… on-demand antitumor immune responses and immune memory, … Although synthetic vaccine
conjugates have clarified … cells is a major goal for most current cancer vaccines. However, …

… Toward this goal, we present a nanotechnology approach to “… multiple overlapping innate
immune pathways could trigger a … promise as vaccine adjuvants that drain to lymph nodes (36). …

… promote lymph node (LN)-targeted delivery in antitumor immune … Hybrid nanoparticle-modified
targeting ligands promoted … LN-targeting and activating the DC-based antitumor immune …

… prophylactic antitumor immunities. Specifically, therapeutic … To further develop lymph
node-targeted delivery of vaccines … synthesized mannose-grafted polymeric nanoparticles to target …

… To further strengthen the anti-tumor immune response … high capacity of draining into lymph
nodes. After being internalized by … Briefly, we obtained target cells from healthy C57BL/6 mice …