T-cell line adaptation of human immunodeficiency virus type 1 strain SF162: effects on envelope, vpu and macrophage-tropism

N Dejucq, G Simmons… - Journal of General …, 2000 - microbiologyresearch.org
… by human immunodeficiency virus type 1 (HIV-1) strains are … strain SF162, selected for
replication in the C8166 T-cell line. … , the loss of macrophage-tropism by one variant was due to a …

HIV-1 replication in CD4+ T cell lines: the effects of adaptation on co-receptor use, tropism, and accessory gene function

N Dejucq - Journal of Leukocyte Biology, 2000 - academic.oup.com
… -1 SF162 adaptation for replication in the C8166 T cell line … a non-functional vpu impairs
macrophage tropism. Thus, in … Biological phenotype of human immunodeficiency virus type 1

… of virus secretion by the human immunodeficiency virus type 1 Vpu protein is cell type independent and occurs in cultured human primary macrophages and …

U Schubert, KA Clouse, K Strebel - Journal of virology, 1995 - Am Soc Microbiol
SF162 (8), inserted into the backbone of the molecular T-cell-… observed previously in HeLa
cells and in the CD4 T-cell line … 5A), suggesting a better adaptation of the primary isolate than …

Effects of vpu start-codon mutations on human immunodeficiency virus type 1 replication in macrophages

KH Richards, PR Clapham - Journal of general virology, 2007 - microbiologyresearch.org
… We used SF162 vpu in all chimeric viruses in this study because its amino acid sequence is
… YU-2, a highly macrophage-tropic strain cloned directly from brain tissue of an AIDS patient, …

Effect of major deletions in the V1 and V2 loops of a macrophage-tropic HIV type 1 isolate on viral envelope structure, cell entry, and replication

L Stamatatos, M Wiskerchen… - … research and human …, 1998 - liebertpub.com
… of HXBc2, a T cell line-adapted HIV-1 isolate, drastically reduce the ability of the mutant …
can affect the T-cell line and macrophage tropism of human immunodeficiency virus type

Mutations in the vpu and env Genes of HIV-1 Can Adversely Impact Infectivity: A Dissertation

KH Richards - 2008 - repository.escholarship.umassmed …
… neutralized T-cell line adapted strain of HIV-1. This data indicates that macrophage-tropism
in … The Human Immunodeficiency Virus (HIV) is an enveloped virus with glycoprotein spikes …

[HTML][HTML] Viral determinants of HIV-1 macrophage tropism

CJA Duncan, QJ Sattentau - Viruses, 2011 - ncbi.nlm.nih.gov
… -adapted R5 HIV-1 isolates (including YU-2, BaL, and SF162) … + T cell recovery after ART
[38]. An interesting report of HIV-… the HIV-1 accessory proteins such as Tat, Nef, Vif and Vpu in …

[图书][B] The molecular basis for HIV-1 monocyte tropism

P Westervelt - 1992 - search.proquest.com
Macrophage tropism determinants of human … range of the human immunodeficiency virus
type-1 (HIV-1) is limited … is their limited tropism for transformed T cell lines, in contrast to HTLV-…

[图书][B] HIV-1 cell tropism

SSY Hwang - 1993 - search.proquest.com
Human Immunodeficiency Virus type 1 (HIV-1) isolates can be … Macrophage-T cell(MT)-tropic
isolates (eg HIV-1 strain BaL) … neutralization is correlated with their macrophage tropism. …

Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations

Y Kiselyeva, R Nedellec, A Ramos, C Pastore… - Journal of …, 2007 - Am Soc Microbiol
1 SF162 isolate (9) selected by viral propagation on CXCR4-expressing T-cell lines acquired
… , and D-10 each have one additional unique mutation that impacts replication capacity and …