… Over 80 years has passed since the discovery of substance P (SP), and a variety of
peptides of the tachykinin (TK) family have been found and investigated. SP, neurokinin A (NKA), …

… In a screen for further biological activities of insect tachykinin-related peptides (TRPs) we
have in the present paper investigated the cardioactive properties of a few TRPs. …

… the implication of tachykinins in cardiovascular regulation at the … that tachykinin receptors
may modulate cardiovascular function … This was addressed by investigating the cardiovascular …

… NKB is the only tachykinin peptide produced from the NKB gene. These Several tachykinin
genes, with … , generate substantial diversity in the tachykinin peptides which can be produced. …

Tachykinins (TKs) constitute the largest vertebrate brain/gut peptide family. Since discovery
of Substance P as a structurally unidentified vasodilatory and contractile compound in 1931, …

… effects of tachykinin agonists and antagonists on respiration and characterize the tachykinin
… and NKB alters cardiovascular function, the effects of these tachykinins on respiration have, …

… ) genes control the synthesis of tachykinin peptides [ 131. While … mechanisms, the two
tachykinin genes generate a family of … The poor selectivity shown by naturally occurring …

… in mammals, and tachykinin peptides were identified and … SP and other tachykinins in the
central nervous system (CNS) … of two other mammalian tachykinins, namely neurokinin A (NKA)…

… We conclude that tachykinin NK 2 receptors do not participate in the physiologic regulation
of resting cardiovascular and … The cardiovascular changes induced by the nonpeptide …

… Tachykinin antagonists may represent useful pharmacological tools to characterize …
tachykinin receptors and to define better the role of these neuropeptides in central cardiovascular …