… One major advantage of this approach is the possibility to isolate highly avid lymphocytes
that recognize their target in a CD8-independent manner because the binding contribution of …

… in vitro for certain types of malignant cells, even … these cytotoxic cells is a matter of controversy
since they do not fit readily into any commonly recognized category of peripheral blood cell…

… human full-term cord blood lymphocytes express a positive natural killer cell activity against
the K-562 target cell … adult peripheral blood and newborn cord blood lymphocytes expressed …

… Lymphocytes in fractions corresponding to peak I displayed either no cytotoxicity or a very
weak cytotoxicity against the target cells, … on the surface of the natural killer cells, attachment of …

… B-cells (CD20+), whereas CD2’ lymphocytes, including T-cells as well as natural killer cells,
… , and in particular which specific lymphocyte subsets, are a direct target for GH. Our method, …

… In addition, among cytokines, only IL-2 and natural killer cell … cytotoxic CD8+ T cells.
Additionally, IL-2 has been demonstrated to enhance target cell recognition by cytotoxic lymphocytes …

… In all cases, there was a greater than 80% decrease in natural killer cellmediated cytotoxicity
against K562 targets in the E-Ros(+) fraction as compared to unseparated PBL or the E-Ros…

… the same time as lymphocytes were added to target ceils. The percentage of BCG-induced
specific boosting of cytotoxicity was calculated by the following formula for triplicate samples: …

… of cells in human peripheral blood that mediate “natural killer… was expressed on cytotoxic
large granular lymphocytes (LGL… microliters of target cells and 100 pI of effector cells at various …

… Isolation of NK cell-enriched lymphocytes. Peripheral blood lymphocytes were isolated
from heparinized venous blood from normal, healthy adult volunteers or from whole-…