… Restoration of contractile function in isolated cardiomyocytes from failing human hearts by
gene transfer of … Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic …

… -mediated gene transfer of SR Ca 2+ -ATPase can modify … of heart failure and in developing
strategies for gene therapy. … a 4% stacking gel in a Miniprotean II cell (Biorad). Proteins were …

… reticulum Ca 2 + ATPase 2a (SERCA2a), which is primarily responsible for sarcoplasmic
reticulum Ca 2… activated as shown by the detection of their target molecules (37). We detected …

… /endoplasmic reticulum Ca 2+ ATPase type 2a (SERCA2a) … cytosolic Ca 2+ back into the
sarcoplasmic reticulum during … identified as a possible gene therapy target as early as 1978 […

… We aimed to characterize the expression of SERCA isoforms in … in cardiomyocytes (CM)
longitudinal sarcoplasmic reticulum (SR), … Restoration of SERCA2a expression by gene transfer …

… SERCA2a as a therapeutic target.Pharmacological agents that … A stable energetic state in
rat hearts was confirmed from 31P … in failing compared with sham LVs, as shown in Figure 2A. …

… in cardiac muscle that are promising targets for gene therapy in … A small Phase II, 3-doses,
randomized, double-blind, placebo… gene therapy of sarcoplasmic reticulum Ca 2+ -ATPase in …

Regulation of the sarcoplasmic reticulum Ca2+-ATPase expression in the hypertrophic and
failing heart This paper is part of a series in the Journal's “Made in Canada” section. The …

… gene transfer technique transiently enhances cardiac … Myocytes were paced at 0.5 Hz
for 5 minutes for stabilization. … or targeted ablation of the phospholamban gene enhances …

… In the heart, the sarcoplasmic reticulum (SR) is a Ca 2+ … In addition, we will also cover the
recent gene therapy of … of SERCA2a as a research target for heart failure treatment. Kho [55] …