… zones that characterize native articular cartilage in vivo. … Results All forms of ADAMTS-4
were active to varying degrees … keratanase II-digested bovine cartilage aggrecan and bovine …

… Full-length ADAMTS-4 (aggrecanase 1) is active on aggrecan … fracture risk and the identification
of new molecular targets … collected by arthroscopy and cultured ex vivo ± NBD (100 µM)…

… injected rats as in vitro 24 and in vivo 25 models, respectively. We … (A) Characterization of
primary cultured chondrocytes was … alone could not block upregulation of ADAMTS-4, MMP-13, …

… activation plays a pivotal role in determining the presumptive joint IZ … Results All forms of
ADAMTS-4 were active to varying … keratanase II-digested bovine cartilage aggrecan and bovine …

… definitive marker for their identification in cartilage tissue. There are, … (C1, 2C) which was
measured using a commercial enzyme-… The aggrecanases ADAMTS-4 and ADAMTS-5 was not …

… Our results determined that mice lack GPNMB has more cartilage damaged … We will
characterize: … The anabolic and catabolic genes will be measured by qPCR in ex vivo culture …

… For this study, we exposed bovine cartilage discs to a high … of the aggrecan core protein with
ADAMTS-4 and ADAMTS-5 as the … models (in vivo), intact joint models (ex vivo), and in vitro …

… from bovine cartilage explants supernatants and active … that active ADAMTS-4 was bound
tightly to the cartilage matrix at … and developed a new competitive ELISA for measuring active …

… synthesis in bovine cartilage [113]. Additionally, in experimental OA mouse models, JAK-…
[124,125], and therefore we have not measured these SMADs with a BRE-TF construct. The …

… with thrombospondin motifs 4 (ADAMTS-4) and ADAMTS-5 and … characteristics and leptin
responses in the cultured cartilage … COX-2 and NO production in OA cartilage ex vivo (Fig. 1). …