Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus

T Hayashi, S Takai, C Yamashita - Current vascular …, 2010 - ingentaconnect.com
peroxisome proliferatoractivated receptor γ (PPAR-γ) among ARBs [75], and PPAR-γ ligands
… reduces platelet activation in rats with streptozotocininduced diabetes mellitus. Pharmacol …

Diabetes, oxidative stress and therapeutic strategies

L Rochette, M Zeller, Y Cottin, C Vergely - Biochimica et Biophysica Acta …, 2014 - Elsevier
Peroxisome proliferator-activated receptors (PPARs) are … 1 diabetes (streptozotocin-induced
diabetic rats and Ins2 Akita … pro- and/or anti-inflammatory mediators to modulate metabolite …

Clofibrate PPARα activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia

L Ibarra-Lara, E Hong, E Soria-Castro… - Journal of …, 2012 - journals.lww.com
… We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated
receptor alpha (… (PPAR) are nuclear receptors activated by specific ligands that regulate gene …

[HTML][HTML] Effects of combination PPARγ agonist and angiotensin receptor blocker on glomerulosclerosis

K Matsushita, HC Yang, MM Mysore, J Zhong… - Laboratory …, 2016 - Elsevier
… I converting enzyme inhibitor (ACEI) and/or angiotensin II … Peroxisome proliferator-activated
receptor-γ (PPARγ) agonists … , activate PPARγ, a ligand-activated nuclear transcription factor …

Phytochemical therapies in vascular functioning: a molecular approach

H Gencoglu, C Orhan, K Sahin - Current vascular …, 2017 - ingentaconnect.com
… its antioxidant and anti-inflammatory actions [27]. Furthermore, another recent study in older,
obese, streptozotocin-induced diabetic rats … and peroxisome proliferator-activated receptor

The cardiovascular protective effects of chrysin: a narrative review on experimental researches

T Farkhondeh, S Samarghandian… - … Agents in Medicinal …, 2019 - ingentaconnect.com
effect is due to its antioxidative effects and antiinflammatory … PDGF receptors and ligands
are markedly increased in … , and pancreas in streptozotocin-induced diabetic rats. Can. J. …

PPARα Stimulation Modulates Myocardial Ischemia-induced Activation of Renin–Angiotensin System

L Ibarra-Lara, M Sánchez-Aguilar, E Hong… - Journal of …, 2015 - journals.lww.com
… that peroxisome proliferatoractivated receptor alpha (… of gene expression 18 upon their
stimulation with ligands. To date… role, promoting anti-inflammatory 19 and antioxidant actions by …

[HTML][HTML] Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19

J Talukdar, B Bhadra, T Dattaroy, V Nagle… - Biomedicine & …, 2020 - Elsevier
anti-inflammatory drugs such as JAK inhibitors, IL-6 inhibitors, TNF-α … profile and has
antioxidant, anti-inflammatory, and immunomodulatory … peroxisome proliferator-activated receptors

PPARγ agonists ameliorate endothelial cell activation via inhibition of diacylglycerol–protein kinase C signaling pathway: role of diacylglycerol kinase

E Verrier, L Wang, C Wadham, N Albanese… - Circulation …, 2004 - Am Heart Assoc
… Subject— Peroxisome proliferator-activated receptor (PPAR)-γ … ’ anti-inflammatory effect
characterized by an inhibition of the … of the ligands binding to PPARγ, 18 suggesting a receptor-…

[HTML][HTML] Coronary microvascular dysfunction in diabetes mellitus: a review

A Picchi, S Capobianco, T Qiu, M Focardi… - World journal of …, 2010 - ncbi.nlm.nih.gov
… the activation of peroxisome proliferator-activated receptor-γ by … anti-inflammatory treatment
be considered among diabetes … Experimental studies in streptozotocin-induced diabetic rats