The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice

DH Hyun, MR Mughal, H Yang, JH Lee, EJ Ko… - Experimental …, 2010 - Elsevier
… decreased in plasma membranes from the hippocampus and cerebral cortex of 3xTgAD mice,
… increased resistance to amyloid β-peptide (Aβ). If and to what extent Aβ is the cause of the …

Redox proteomics and amyloid βpeptide: insights into Alzheimer disease

DA Butterfield, D Boyd‐Kimball - Journal of neurochemistry, 2019 - Wiley Online Library
… synaptic plasticity and cell structure, neuroinflammation, impaired protein folding … Redox
proteomics analysis of carbonylated proteins in the hippocampus of 3-month-old 3xTg-AD mice

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

ML Young, JL Franklin - Molecular and Cellular Neuroscience, 2019 - Elsevier
… cognitive impairment and dementia coincident with progressive damage to brain neuronal
… include the development of extracellular amyloid plaques in the brain and the formation of …

iTRAQ analysis of complex proteome alterations in 3xTgAD Alzheimer's mice: understanding the interface between physiology and disease

B Martin, R Brenneman, KG Becker, M Gucek… - PloS one, 2008 - journals.plos.org
impairment associated with accumulation of amyloid … APP), resulting in the accumulation of
amyloid β-peptide (Aβ) and the … Syntaxins are a group of synaptic plasma membrane proteins …

[HTML][HTML] Mitochondrial molecular abnormalities revealed by proteomic analysis of hippocampal organelles of mice triple transgenic for Alzheimer disease

H Yu, X Lin, D Wang, Z Zhang, Y Guo, X Ren… - Frontiers in molecular …, 2018 - frontiersin.org
… swollen cells to gently lyse the cell membrane. Then, 150 μL … 3xTg-AD mice showed a trend
of mild learning impairment in … , key players in cellular redox function and protection against …

Convergence of amyloid-β and tau pathologies on mitochondria in vivo

A Eckert, KL Schulz, V Rhein, J Götz - Molecular neurobiology, 2010 - Springer
… when cortical brain cells of P301L tau transgenic pR5 mice … Similarly, cognitive impairment
manifested in 3xTg-AD mice … in another triple transgenic mouse model 3xTg-AD (P301Ltau/…

Accumulated amyloid-β peptide and hyperphosphorylated tau protein: relationship and links in Alzheimer's disease

HC Huang, ZF Jiang - Journal of Alzheimer's disease, 2009 - content.iospress.com
… and dephosphorylation is disturbed in neurons. Accumulated … and 4 months in the neocortex
of 3xTg-AD mice, while the Aβ … fibrillar forms of Aβ to plasma membrane proteins has been …

Amyloid-β peptide Aβ3pE-42 induces lipid peroxidation, membrane permeabilization, and calcium influx in neurons

AP Gunn, BX Wong, T Johanssen, JC Griffith… - Journal of Biological …, 2016 - ASBMB
… peroxidation in primary cortical mouse neurons compared with the … Aβ3pE-42 further caused
a loss of plasma membrane integrity … oligomer formation mediated by copper-redox cycling. …

Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

D Liu, M Pitta, H Jiang, JH Lee, G Zhang, X Chen… - Neurobiology of …, 2013 - Elsevier
Impaired brain energy metabolism and oxidative stress are … and the pathologic accumulations
of amyloid β-peptide (Aβ) and … in cerebral cortex of NAM-treated 3xTgAD mice compared …

[HTML][HTML] Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease

S Camandola, MP Mattson - … et Biophysica Acta (BBA)-Molecular Cell …, 2011 - Elsevier
… -aggregation of the amyloid β-peptide which can generate … and AD is the plasma membrane
(PM) redox system (PMRS). … in brain tissue samples from AD patients and 3xTgAD mice, …