… methods to evaluate the activity of drugs are introduced. … Finally, by performing time-kill
assays, researchers can obtain … To sum up, in this section, we reviewed the strategies of DST …

… The role of the time-kill kinetics assay as part of a preclinical modeling framework for
assessing the activity of anti-tuberculosis drugs. Tuberculosis (Edinb) 105:80–85. …

… in whole-cell assays to evaluate their activity against the … tuberculosis, or in time-kill curves
to have their mechanism of … in toxicology studies during preclinical development. However, it …

… time-kill assays obtained from high-throughput screening in early discovery are used to
calculate PK-PD target calculations in late preclinical … in vitro assessment of drug activity, since …

… phase 2A studies to assess early bactericidal activity (EBA), … a PKPD model of Mycobacterium
tuberculosis killing kinetics … drug contributions to BPaZ were also illustrated with time-kill …

… vitro time-kill experiments and therefore in those cases fixed to 0. … PK/PD models for translation
from preclinical to clinical … in a comparative biodistribution assessment of Lee 1599 after …

… and time-consuming animal pre-clinical and human clinical trials. … environments with first
order kinetics detailed in Appendix C. … drugs and regimens, allowing a rapid assessment of drug …

… Models with static drug concentrations evaluate how a bacterial … toxic side effects related to
individual drugs and decreasing … time kill curves from the HFIM, we used an integrated PK/PD …

… time-kill assays obtained from high-throughput screening in early discovery are used to
calculate PK-PD target calculations in late preclinical … in vitro assessment of drug activity, since …

… Static drug concentration models Static models evaluate the … bactericidal concentration and
quantitative time-kill curves, are … The path of anti-tuberculosis drugs: from blood to lesions to …