… in toxicology studies during preclinical development. However, it … in whole-cell assays to
evaluate their activity against the … tuberculosis, or in time-kill curves to have their mechanism of …

… exposure and response, time-kill kinetics of pretomanid against … comes from in vitro and
preclinical studies. No mutagenic or … One study used modeling and simulation to evaluate the …

… similar motif was present in the preclinical TB candidate BTZ043 (2,… We also assessed the
ability of 12 and 13 to eradicate … The time–kill profile of 1 was determined separately, and here …

… The role of the time-kill kinetics assay as part of a preclinical modeling framework for
assessing the activity of anti-tuberculosis drugs. Tuberculosis. 2017;105:80–85. …

… new drug evaluation criteria to allow the assessment of … , any adaptation of MIC or time-kill
assay that ensures that the … for evaluating the activity of a drug in preclinical assays that are …

… Despite this importance, methods for determining numbers of … E max models applied to
time-kill data from FCM defined cell … study of mycobacteria in preclinical drug development and …

… for improved activity of spectinamides and to evaluate their … with a delay function for the
time-kill effect of the drug was fit … preclinical as well as clinical development, PK/PD modeling …

… carpunya and to evaluate its biological activities. A phytochemical … Ames test was finally
performed to assess safety of P. … carpunya EO with fluconazole was confirmed by time-kill curve …

… The time-kill kinetics of antibacterial agents is an important indicator of their in vitro …
component of the preclinical drug model framework [38,39]. To evaluate the bactericidal ability of …

… laboratory testing strategies for assessing phage activity … and time-kill analyses have
been used to assess potential … mathematical modeling of preclinical infection model data (164…