… the preclinical environment as a complementary tool to existing anti-tuberculosis research …
With time-kill experiments, the growth and killing kinetics of a pathogen are followed over time …

… preclinical tool to explore the effectiveness of various drug … The in vitro activity against a
pathogen over time is most … A robust system to evaluate the efficacy of antibiotic combinations in …

… patients, determining optimal dosing of antimicrobial agents for … over time (time-kill curves)
offer a more robust approach. … The mechanism controlling the activity of antimicrobial agents …

… to measure anti-tuberculosis (TB) drug activity in sputum … disposition kinetics was used
as the basis for the simulation … a platform for advanced preclinical testing in pharmaceutical …

… Since our predictions are based on pre-clinical data, our … mutations in the resistance
determining region of the rpoB … is a metric of cumulative antibacterial activity over that time period …

… the bactericidal activity of rifampicin in time-kill studies and also … : i) the development of
preclinical candidates including … mouse model of systemic infection was used to evaluate the role …

… (PK/PD) of anti-tuberculosis drugs, various mathematical and … determining the MIC using
various methods, time-kill kinetic … modeling approach can bridge the translation of pre-clinical …

… carpunya and to evaluate its biological activities. A … Ames test was finally performed to
assess safety of P. … Time-kill analysis showed that the mixture of P. carpunya EO and …

… Figure 3.21 Time-kill curves of meropenem/linezolid 4/32 μg/… Antibacterial Agents in
Clinical and Preclinical Development … It can be used to evaluate and prioritize potential drug …

… Yet part of the immediate response to this continuing crisis must also be to critically evaluate
… In mathematical models of drug action and the emergence of resistance, the existence of at …