… caused by the failure of proper neural tube closure during early embryonic development. …
Genetic and environmental factors are both involved in the etiology of NTDs. Genetic factors …

… NTD aetiology is multifactorial and includes environmental and genetic factors.3 … Finding
a genetic risk factor in the receptor required for cobalamin bioavailability further establishes the …

… genetic factors, interfamilial marriage and nutritional factors as … , we think that the most
important finding from this study is the … In this study, we search for another genetic folate risk factor, …

… genetic factors, variations in MTHFR gene have been assessed as potential risk factors in …
keywords and terms were used search the eligible studies: (‘‘Neural Tube Defects’’ OR ‘‘NTDs’…

… multifactorial genesis with both environmental and genetic factors. One environmental factor
… Our finding of normal homocysteine levels in NTD cases, even when stratified by genotype, …

… caused by genetic factors and 80% by non-genetic factors, but … between environmental
and genetic factors, which affects the … Researches showed that the formation of neural tube is …

… Growing data from epidemiological case–control studies have shown that genetic factors
may … The search strategy was based on English keywords, “MTHFR”, “MTRR”, “RFC”, “folate …

… The biochemical and genetic determinants underlying the protective effects of folates are
currently unknown. It is unclear whether periconceptional folate intake overcomes disturbed …

… best explanation for neural tube defects (NTDs) in humans. Ev… With the multi-site NT closure
model, we find that the majority of … factors could account for the genetic susceptibility to NT …

… Neural-tube defects such as anencephaly and spina bifida constitute a group of common …
genetic and environmental factors. We have identified three mutations in the VANGL1 gene in …