… This finding is compatible with stimulation by a Vβ8-specific superantigen possibly … a
superantigen type of recognition we searched for a conserved motif in the CDR3 region (Table 2). …

… The structure revealed the presence of a secondary zinc-binding site close to the major
histocompatibility complex (MHC)-binding … The rms deviation of main-chain atoms in this region …

… gous superantigen that demonstrates only a single MHC class … binding sites on ma.jor
histocompatibility complex class 11. J. … structural motif for binding class II major histocompatibility …

… Superantigens (SAgs) are potent microbial toxins that bind simultaneously to T cell receptors
(TCRs) and class II major histocompatibility complex … stock solution and/or well solutions …

… bind to major histocompatibility complex (MHC) class II molecules outside the peptide-binding …
out with SAgs that bind to the MHC class II α-chain via the N-terminal domain (SEB, TSST-…

… superantigens (47) has provided us with new insights into possible mechanisms of pathogenesis.
The SE and TSST specifically bind classII major histocompatibility complex (… the region …

… an unexpected structural homology with the C-terminal domain of bacterial superantigens,
a class of … binding both major histocompatibility class II proteins and T-cell receptors (TCRs) …

… type I integral membrane proteins with small cytoplasmic domains and large extracellular
domains… very carefully, there will be only one type of MHC in solution. Then, as shown in the …

… class II transmembrane domain to drive both M1 and M2 … Major histocompatibility complex
(MHC) class II molecules are … other class II functions such as peptide binding, super-antigen …