… basis of IRF-3 activation upon phosphorylation is … structures of phosphorylated human and
mouse IRF-3 bound to CREB-binding protein (CBP), which reveal that phosphorylated IRF-3 …

… Here we show that the pLxIS motif of phosphorylated STING, MAVS, and TRIF binds to
IRF-3 in a similar manner, whereas residues upstream of the motif confer specificity. The …

… infection induces phosphorylation and activation of IRF-3 to initiate the antiviral responses.
The crystal structure of the IRF-3 transactivation domain … Structural basis of autoinhibition …

… the dimerization of IRF-3 and phosphorylation of the … structure of IRF-3 175C and mutational
analyses of IRF-3, we proposed the phosphorylation-induced dimerization as the activation …

… that the phosphorylated residues of IRF-3 directly participate in … The structural basis for
the versatility of the IBiD in … whether IRF-3(173-394) can compete with Sendai virus-activated, …

… activation. Servant and colleagues demonstrated that phosphorylation of latent cytoplasmic
IRF-3 … 3), these results provide a structural basis for the coupling between dimerization and …

… 339 and serine 396 in the ability of IRF-3 to induce expression of the interferon-… IRF-3
activation. We propose that conventional biochemical assays used to measure IRF-3 activation …

… phosphorylation of IRF-3 leads to cytoplasmic to nuclear translocation of phosphorylated
IRF-3, … that virus-stimulated phosphorylation of IRF-3 results in the activation of the immediate-…

… The main conclusion of this study is that dimerization of IRF-3, caused by its phosphorylation,
is the sole reason for the increased ability of this transcription factor to bind its target DNA …

… , especially on the phosphorylation sites, the oligomerization … , the phosphorylated IRF-3
regulatory domain (IRF-3 RD) … phosphorylation of Ser386 is essential for activation of IRF-3. …