TAM Receptor–Dependent Regulation of SOCS3 and MAPKs Contributes to Proinflammatory Cytokine Downregulation following Chronic NOD2 Stimulation of Human …

S Zheng, M Hedl, C Abraham - The Journal of Immunology, 2015 - journals.aai.org
… The role of Tyro3, Axl, and Mer (TAM) receptors in regulating … Axl and Mer were similarly
required in mice for cytokine … after chronic systemic MDP treatment in Axl/Mer −/− mice in vivo. In …

Research progress of TAM receptor tyrosine kinase

Z Liwen, C Zhaohong - Chinese Journal of Nephrology, Dialysis & …, 2019 - njcndt.com
Therapeutic efficacy of TYRO3, AXL, and MER tyrosine kinase agonists in collageninduced
arthritis.Arthritis Rheum,2013,65(3): 671⁃680. …

Apoptotic cell clearance: basic biology and therapeutic potential

IKH Poon, CD Lucas, AG Rossi… - Nature Reviews …, 2014 - nature.com
… αVβ3 integrin and the Tryo3–AxlMer (TAM) family of receptors … -protein kinase MER (a
member of the TAM family) on the … agonists has been demonstrated to have beneficial effects in …

[HTML][HTML] Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor

G Zhao, J Zheng, J Bian, L Chen, N Dong… - Mediators of …, 2017 - hindawi.com
… In this view, Treg cell-based therapies have held great … with receptor tyrosine kinases of the
TAM family; Tyro3, Axl, … Matsushima, “A novel receptor tyrosine kinase, mer, inhibits TNF-𝛼 …

[HTML][HTML] Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages

F Wanke, S Gutbier, A Rümmelin, M Steinberg… - Cell death & …, 2021 - nature.com
… (PtdSer), the TAM family of receptor tyrosine kinases (RTKs) has been … TYRO3 (also known
as BYK, DTK, RSE, SKY, and TIF), AXL (… We next tested whether the TAM RTK agonist GAS6 …

[PDF][PDF] Local soluble MER levels are enhanced in rheumatoid arthritis and positively correlate with GAS6

CEJ Waterborg, J Vullings, MI Koenders… - … roles of AXL and MER … - repository.ubn.ru.nl
… that the TAM receptor MER plays a protective role in models of rheumatoid arthritis (RA). …
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

Association of plasma levels of Protein S with disease severity in multiple sclerosis

GZM Ma, LL Giuffrida, MM Gresle… - Multiple Sclerosis …, 2015 - journals.sagepub.com
… The TAM family of receptor tyrosine kinases (TYRO3, AXL and MERTK) play important …
Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis

M Koenen, S Culemann, S Vettorazzi… - Annals of the …, 2018 - ard.bmj.com
… of CD163, CD36, AnxA1, Axl and MerTK after 72 hours of DEX treatment in wt→wt and wt→…
increase therapeutic benefits in collagen-induced arthritis36 and adjuvant arthritis in rats.37 …

[HTML][HTML] The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis

M Cutolo, R Campitiello, E Gotelli… - Frontiers in …, 2022 - frontiersin.org
… -activated protein kinases/mitogen-activated protein kinases (… also identified in a
collagen-induced arthritis (CIA) mouse … CD206), and the MER proto-oncogene, tyrosine kinase

… -Immune Complex Mediated Proportional and Functional Changes of Specific NK-Cell Subsets in Early Seropositive but not Seronegative Rheumatoid Arthritis

P Chalan, E Brouwer, J Bijzet, BJ Kroesen, M Boots - 2015 - ard.bmj.com
tyrosine kinaseArthritis (RA) patients Gas6 plasmatic level is decreased compared to
healthy subjects1 while the over-expression of MerTK agonists in collagen-induced arthritis