[HTML][HTML] Molecular mechanism of pancreatic stellate cells activation in chronic pancreatitis and pancreatic cancer

G Jin, W Hong, Y Guo, Y Bai, B Chen - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
cancer progression by increasing proliferation, invasiveness and … that a hypoxic environment
exists not only in cancer cells, but … the interaction of PSCs and pancreatic cancer cells 78 . …

Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells

I Rosová, M Dao, B Capoccia, D Link, JA Nolta - Stem cells, 2008 - academic.oup.com
… respond to HGF and hypoxia through Akt and Erk signaling pathways, we further examined
… in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met

The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance

M Erkan, C Reiser-Erkan, CW Michalski… - Current molecular …, 2012 - ingentaconnect.com
… fibrotic/hypoxic milieu of pancreatic cancer through abnormal … dramatic rearrangement of
tumor-stromal interactions. It has … hepatocyte growth factor—in pancreatic stromal cells causes …

Inhibition of MIF leads to cell cycle arrest and apoptosis in pancreatic cancer cells

A Denz, C Pilarsky, D Muth, F Rückert… - Journal of Surgical …, 2010 - Elsevier
… of early diagnosis and its highly invasive and metastatic features, … Pancreatic cancer is
characterized by a hypoxic … Looking for an interaction between the apoptosis inhibiting MIF and …

Inhibition of tumorstromal interaction through HGF/Met signaling by valproic acid

Y Matsumoto, T Motoki, S Kubota, M Takigawa… - Biochemical and …, 2008 - Elsevier
… for cancer cell invasion mediated by tumorstromal interactions. We … the HGF and Met
pathway in the tumorstromal interaction and we … : evidence for a role of hepatocyte growth factor …

Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

JA McCarroll, S Naim, G Sharbeen, J Lee… - Frontiers in …, 2014 - frontiersin.org
hepatocyte growth factor and c-met in pancreatic cancer tissue … cells, it is the stem cells
that gain the more invasive phenotype. Hypoxia in pancreatic cancer also selects for cancer cell

[PDF][PDF] Nicotine Reduces Survival via Augmentation of Paracrine HGF-MET Signaling in the Pancreatic Cancer Microenvironment 2

GA Vlada, KE Behrns, RM Thomas, X Lu, C Liu… - researchgate.net
… 263 growth, invasion, metastasis and chemoresistance viaCancer-stellate cell interactions
perpetuate the hypoxia-… 620 hepatocyte growth factor/c-MET pathway in pancreatic stellate …

FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer

S Nomura, H Yoshitomi, S Takano, T Shida… - … journal of cancer, 2008 - nature.com
cellular invasion and metastasis of pancreatic cancer cells. Cellular and genetic studies have
shown that tumour growth … hypothesized that stromal cellcancer cell interactions have an …

[HTML][HTML] MET: roles in epithelial-mesenchymal transition and cancer stemness

HM Jeon, J Lee - Annals of translational medicine, 2017 - ncbi.nlm.nih.gov
… MET and its ligand hepatocyte growth factor (HGF) (also known as … In prostate and pancreatic
cancer, both HGF and MET are … cancer, MET amplification significantly increased invasive

An overview of the c-MET signaling pathway

SL Organ, MS Tsao - Therapeutic advances in medical …, 2011 - journals.sagepub.com
… , hepatocyte growth factor, activates a wide range of different … proliferation, motility, migration
and invasion. Although c-MET … Hypoxia, caused by lack of oxygen diffusion to the centre of a …