VEGF-A and blood vessels: a beta cell perspective

W Staels, Y Heremans, H Heimberg, N De Leu - Diabetologia, 2019 - Springer
islet graft failure and graft loss. This review summarises our understanding of the role of
vascular endothelial growth factor-Athat promoting early graft vascularisation in clinical islet

VEGF-A: the inductive angiogenic factor for development, regeneration and function of pancreatic beta cells

KO Lui - Current stem cell research & therapy, 2014 - ingentaconnect.com
… In addition to promoting survival of pancreatic islets, in this … ECs is necessary to maintain
proper intra-islet vascularisation, … growth factor-A signaling, promotes beta cell regeneration. …

… insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice

N Iwashita, T Uchida, JB Choi, K Azuma, T Ogihara… - Diabetologia, 2007 - Springer
islet capillary network is about five times denser than that of … of pancreatic islets consists
of thin fenestrated endothelial cells … suggest that disorganisation of islet vascularisation can …

Role of VEGF-A in pancreatic beta cells

H Watada - Endocrine journal, 2010 - jstage.jst.go.jp
… on the increase in beta-cell mass by BMT, we analyzed pancreatic islets of RIP-Cre… Pancreatic
islet production of vascular endothelial growth factor--a is essential for islet vascularization

Colocalization of vascular endothelial growth factor (vascular permeability factor) and insulin in pancreatic islet cells

M Kuroda, T Oka, Y Oka, T Yamochi… - The Journal of …, 1995 - academic.oup.com
… , selectively stimulates endothelial cell growth and angiogenesis (6… strongly with the normal
adult pancreatic islets of Langerhans … Vascular endothelial growth factor: a new member …

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Y Xiong, MJ Scerbo, A Seelig, F Volta, N O'Brien… - Elife, 2020 - elifesciences.org
… in islet vascularization is vascular endothelial growth factor-A (VEGF-… the vascularization of
pancreatic islets. Importantly, there was … Here we suggest that there is an important, albeit not

[HTML][HTML] Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats

Y Cheng, YF Liu, JL Zhang, TM Li… - World Journal of …, 2007 - ncbi.nlm.nih.gov
Islet survival depends on the diffusion of oxygen and nutrients. Pancreatic islets are heavily
vascularizedIslet capillaries are fenestrated, which may be important for the efficient release …

Islet Endothelial Cells and Pancreatic β-Cell Proliferation: Studies in Vitro and during Pregnancy in Adult Rats

M Johansson, G Mattsson, A Andersson… - …, 2006 - academic.oup.com
… from the islets, such as vascular endothelial growth factor-A (… an endothelial-endocrine axis
within adult pancreatic islets, … during β-cell growth and islet angiogenesis. For this purpose, …

Vascular endothelial growth factor–mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass

J Agudo, E Ayuso, V Jimenez, A Casellas, C Mallol… - Diabetes, 2012 - Am Diabetes Assoc
islet vascularization and inflammation was parallel to an increased expression of vascular
endothelial growth factor A (VEGF). … in pancreatic islets from insulin-resistant HFD-fed mice. A: …

The role of vascular endothelial growth factor-A (VEGF-A) in pancreatic islet function in adults

JA Kantz - 2009 - ir.vanderbilt.edu
… of VEGF-A in pancreatic islets and the subsequent effects this … of islet vascularization, in
adult islet vasculature and function. … indicate that VEGF-A in adult islets also plays an important