Improvement of rat islet viability during transplantation: validation of pharmacological approach to induce VEGF overexpression
A Langlois, W Bietiger, E Seyfritz… - Cell …, 2011 - journals.sagepub.com
… Vascular endothelial growth factor (VEGF) could play a … for VEGF overexpression in
pancreatic islets using the iron … in pancreatic islets, to improve angiogenesis and graft function, …
pancreatic islets using the iron … in pancreatic islets, to improve angiogenesis and graft function, …
The biology of vascular endothelial growth factors
T Tammela, B Enholm, K Alitalo… - Cardiovascular …, 2005 - academic.oup.com
… the angiogenesis field, the vascular endothelial growth factors … However, VEGF-C is not
essential for the development of … Furthermore, overexpression of VEGF-C in pancreatic islet cell …
essential for the development of … Furthermore, overexpression of VEGF-C in pancreatic islet cell …
Epidermal growth factor receptor regulates pancreatic fibrosis
SA Blaine, KC Ray, KM Branch… - … Journal of …, 2009 - journals.physiology.org
… previously shown that overexpression of HB-EGF in pancreatic islets leads to disrupted islet
… the Waved-2 background, demonstrating that EGFR activity was not required for the onset of …
… the Waved-2 background, demonstrating that EGFR activity was not required for the onset of …
The role of accessory cells in islet homeostasis
SC Tang, CF Jessup, M Campbell-Thompson - Current diabetes reports, 2018 - Springer
… Pancreatic islets are extraordinarily vascular, receiving 10–… During early pancreatic
development, vascular endothelial … of appropriately vascularized, properly functioning islets [20, …
development, vascular endothelial … of appropriately vascularized, properly functioning islets [20, …
Formation of a human β-cell population within pancreatic islets is set early in life
BE Gregg, PC Moore, D Demozay… - The Journal of …, 2012 - academic.oup.com
… , adult pancreatic β-cells are found at the core of an islet with … associated with pancreatic
islets are also important for their … be set even earlier, during pancreatic development. Moreover, …
islets are also important for their … be set even earlier, during pancreatic development. Moreover, …
Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function
J D'Hoker, N De Leu, Y Heremans, L Baeyens… - Diabetes, 2013 - Am Diabetes Assoc
… that vascularization and oxygenation of pancreatic islets are … and that signaling by vascular
endothelial growth factor (VEGF) … still attribute an important role to the islet endothelium, since …
endothelial growth factor (VEGF) … still attribute an important role to the islet endothelium, since …
Growth factors and beta cell replication
RC Vasavada, JA Gonzalez-Pertusa, Y Fujinaka… - The international journal …, 2006 - Elsevier
… very important constraint. There is a critical paucity of pancreatic islets or pancreatic beta cells
for islet … in vivo, such as increased vascularization, circulating or local IGF effects, or other …
for islet … in vivo, such as increased vascularization, circulating or local IGF effects, or other …
Angiopoetin-2 signals do not mediate the hypervascularization of islets in type 2 diabetes
P Shah, N Lueschen, A Ardestani, J Oberholzer… - PLoS …, 2016 - journals.plos.org
… Islet angiogenesis is promoted by three major families of angiogenic factors; vascular
endothelial growth … area within the pancreatic islets by CD31/PECAM-1, located on the surface of …
endothelial growth … area within the pancreatic islets by CD31/PECAM-1, located on the surface of …
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
T Kamba, BYY Tam, H Hashizume… - … Journal of …, 2006 - journals.physiology.org
… of the doses that we used may have been higher than necessary to … of the reduced vascularity
of pancreatic islets after VEGF … We reasoned that if the loss of islet capillaries resulted in a …
of pancreatic islets after VEGF … We reasoned that if the loss of islet capillaries resulted in a …
Factors controlling pancreatic islet neogenesis.
A Vinik, G Pittenger, R Rafaeloff… - The Yale Journal of …, 1992 - ncbi.nlm.nih.gov
… , but also with neovascularization of the new islet [27]. The … replication of the pancreatic islets
during the development of the … ME, Derynck R: Transforming growth factor-a: A more potent …
during the development of the … ME, Derynck R: Transforming growth factor-a: A more potent …