… sclerosis. What is often referred to as the normal appearing white matter in MRI studies, can
be demonstrated to possess features of disease … subtypes of multiple sclerosis. In particular, …

… These pale areas are sometimes referred to as “shadow plaques.” At least some such
areas are likely to represent areas of remyelination [17]. Pathology studies indicate that …

… Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system.
In around 85% of cases, the disease progresses through two distinct stages: relapsing-remitting …

… After the acute demyelinating phase, the lesions can develop into gliotic scar tissue (sclerosis),
and become chronic active or inactive lesions or they may remyelinate to form shadow …

… Using A mode ultrasound, Serup [14], showed that plaques of clinically advanced scleroderma
were thicker than plaques of slight scleroderma. The relative increase in thickness was …

… ABSTRACT: In this review, new insights into the immunopathogenesis of multiple
sclerosis (MS) are discussed, with special focus on the potential mechanisms leading to …

… conditions – amyotrophic lateral sclerosis, multiple sclerosis and Alzheimer's disease – with
emphasis on key cellular changes that may underlie early axonal dysfunction and pathology …

… disorders of the CNS can very roughly be subdivided into diseases that are mainly mediated
by deregulated cellular immune response, eg multiple sclerosis, by pathological humoral …

Oligodendrocytes are the principal target of immune attack in multiple sclerosis (… could
prevent microglial induced oligodendrocyte toxicity and could lead to strategies to slow disease …

… occur in systemic scleroderma. Calcinosis cutis in localized … Werner syndrome is an inherited
disorder that leads to … These processes usually occur on the aggregates of shadow cells. …