… The results of the present study demonstrate that p21 acts as a negative regulator of cellular
p53 levels in two human cell lines of different tissue types. The finding that the protease/…

… The p21 CDKN1A gene was previously known with different abbreviations, such as WAF1
(wild-type p53-… activity by driving its localization and by regulating the protein stability. …

… nuclear localisation and stability of CDKN1A/p21 [14]. Human interacting proteins of … of
mesenchymal markers, suggesting that CDKN1A/p21 is a negative regulator of EMT, and may …

… Reversible protein phosphorylation by diverse kinases serves as an additional posttranslational
mechanism controlling p21′s function, localization, binding partners, stability and …

… The p21 CDKN1A protein is an important player in the maintenance of genome stability
through … In the DNA damage response, p21 interacts with specific proteins to integrate cell-cycle …

… Following p53 activation, transcription of p21/CDKN1A is strongly induced as a direct target
… Thus, p27 stabilization will cause hypophosphorylation of p130 and subsequent DREAM …

… ) into asynchronously growing HMECs immortalized by stable integration of human
telomerase (… observed in cells depleted of negative regulators of S-phase entry (eg, Rb [Citation39]). …

… inducible transcription activation of CDKN1A. BOZF1 is unique … , and it inhibited p53 acetylation
without affecting p53 stability. … is a negative regulator of tumor suppressors p53 and p21. …

… p53, p21 WAF/CDKN1A is a major negative regulator of cell cycle progression and we observed
increased in p21 expression by p53. … p53 expression by controlling protein stability, and …

… of the transcriptional activation and repression of CDKN1A.By … after DNA damage in
the absence of p21 stabilization.… Cdk inhibitors: Positive and negative regulators of g1-phase …