… poor clopidogrel response have not yet been fully elucidated. In this review, we systematically
summarized numerous factors affecting the pharmacodynamics and pharmacokinetics of …

Pharmacokinetic (PK) and pharmacodynamic (PD) studies have proven to be powerful and
instructive tools, particularly in elucidating important aspects of human pharmacology. …

… We have learned that newer indexes of pharmacodynamic response, such as AUIC, seem
… Ultimately, if we utilize these pharmacokinetic and pharmacodynamic principles correctly, …

… the role of pharmacokinetics or even homeostatic regulation in the pharmacodynamic
response. … –effect relationship and accurate individual pharmacodynamic estimates [eg (E max ) …

… distinguished the pharmacokinetic and pharmacodynamic sources of variability in response
to a dose and offers practical advice for implementation of exposure response analysis. …

… the changes in the pharmacokinetics of drugs caused … pharmacokinetics and
pharmacodynamics of cytotoxic agents. We argue that, overall, these factors identify inflammatory …

… pharmacodynamics: Application to d-tubocurarine We propose a model of drug pharmacodynamic
response that when integrated with a pharmacokinetic model allows characterization …

… A lower pharmacodynamic response has been linked to a … that a reduced pharmacodynamic
response to clopidogrel is … prasugrel pharmacokinetics or pharmacodynamic response. …

… of pharmacokinetic–pharmacodynamic (PK/PD) modelling has made many advances from
the basic concept of the dose–response … of the concentration–response relationship from the …

… not only by pharmacokinetic processes, but also by pharmacodynamic processes. Therefore,
the variability in drug response is a result of the variability in either pharmacokinetic or …