scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

SJ Clark, R Argelaguet, CA Kapourani… - Nature …, 2018 - nature.com
… ’s transcriptome is profiled using a conventional Smartseq2 protocol 10 . To … chromatin
accessibility together with DNA methylation, we adapted Nucleosome Occupancy and Methylation

Joint profiling of chromatin accessibility and gene expression in thousands of single cells

J Cao, DA Cusanovich, V Ramani, D Aghamirzaie… - Science, 2018 - science.org
… indexing–based coassay that jointly profiles chromatin accessibility and mRNA (CAR) in …
3 sci-CAR enables joint profiling of chromatin accessibility and transcription in mouse kidney…

[HTML][HTML] Protocol for scChaRM-seq: Simultaneous profiling of gene expression, DNA methylation, and chromatin accessibility in single cells

R Yan, X Cheng, F Guo - STAR protocols, 2021 - Elsevier
… -cell RNA sequencing, DNA methylation, and chromatin accessibility allows a multimodal …
seq (single-cell chromatin accessibility, RNA barcoding, and DNA methylation sequencing), …

Single-cell multi-omics profiling links dynamic DNA methylation to cell fate decisions during mouse early organogenesis

SJ Clark, R Argelaguet, T Lohoff, F Krueger, D Drage… - Genome biology, 2022 - Springer
… scRNA-seq and targeted scNMT-seq to profile E8.5 embryos, … quantified DNA methylation
and chromatin accessibility levels … , chromatin is remodelled to allow accessibility to the DNA, …

Genome-wide profiling of nucleosome position and chromatin accessibility in single cells using scMNase-seq

W Gao, B Lai, B Ni, K Zhao - Nature protocols, 2020 - nature.com
… regions; and the scNOMe-seq, scNMT-seq and scCOOL-seq … measures chromatin
accessibility, DNA methylation and … scMNase-seq enables the detection of genome-wide …

Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes

C Gu, S Liu, Q Wu, L Zhang, F Guo - Cell research, 2019 - nature.com
… scCOOL-seq 29,30 , scNOMe-seq 31 and scNMT-seq 32 , that can simultaneously analyse
DNA … So, we analysed dynamics of both the chromatin accessibility and DNA methylation of …

Multi-omics profiling of mouse gastrulation at single-cell resolution

R Argelaguet, SJ Clark, H Mohammed, LC Stapel… - Nature, 2019 - nature.com
… map of chromatin accessibility, DNA methylation and RNA … Recent technological advances
have enabled the profiling of … sequencing 12 (scNMT-seq) to profile 1,105 single cells …

Advances and challenges in epigenomic single-cell sequencing applications

M Philpott, AP Cribbs, T Brown Jr, T Brown Sr… - Current Opinion in …, 2020 - Elsevier
… , methylation and transcription sequencing (scNMT-seq) [17], … as chromatin accessibility,
chromatin and transcription factor … ], DNA methylation, proteomic profiling and genomic profiling

Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing

I Lee, R Razaghi, T Gilpatrick, M Molnar, A Gershman… - Nature …, 2020 - nature.com
… -specific profiles of DNA methylation and accessibility on a human genome. We compared …
Our long nanopore reads also allow detection of structural variants, large insertions, deletions …

[HTML][HTML] Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing

R Yan, C Gu, D You, Z Huang, J Qian, Q Yang… - Cell Stem Cell, 2021 - cell.com
… We observed a global increase in DNA methylation during human oocyte growth that …
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in …