'Rejuvenation'protects neurons in mouse models of Parkinson's disease
CS Chan, JN Guzman, E Ilijic, JN Mercer, C Rick… - Nature, 2007 - nature.com
… in adult neurons induces a reversion to the juvenile form of pacemaking. Such blocking (‘rejuvenation’)
protects these neurons in both in vitro and in vivo models of Parkinson’s disease, …
protects these neurons in both in vitro and in vivo models of Parkinson’s disease, …
New agents promote neuroprotection in Parkinson's disease models
C Maria Miranda Santos - CNS & Neurological Disorders-Drug …, 2012 - ingentaconnect.com
… Neuroprotection refers to the protection of neurons from … dopamine neurons in a rodent
model of Parkinson's disease. … Rejuvenation Res., 2009, 12(4), 259-267. [50] Maguire-Zeiss, K.…
model of Parkinson's disease. … Rejuvenation Res., 2009, 12(4), 259-267. [50] Maguire-Zeiss, K.…
Wnt/β-catenin signaling is required to rescue midbrain dopaminergic progenitors and promote neurorepair in ageing mouse model of Parkinson's disease
F L'Episcopo, C Tirolo, N Testa, S Caniglia… - Stem Cells, 2014 - academic.oup.com
… is restored via “astrocyte rejuvenation”-induced Wnt1 expression or under Wnt/β-catenin
activation regimens, such as GSK-3β antagonism, leading to DA neuron formation. Together, …
activation regimens, such as GSK-3β antagonism, leading to DA neuron formation. Together, …
Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease
S Ben Youssef, G Brisson… - Nutritional …, 2021 - Taylor & Francis
… protected against neuronal loss and improved motor function in an in vivo 6-OHDA model of
Parkinson’s disease (PD)… to protect dopamine neurons from degeneration in a model of PD. …
Parkinson’s disease (PD)… to protect dopamine neurons from degeneration in a model of PD. …
The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson'disease mice
Q Miao, Z Chai, LJ Song, Q Wang, GB Song… - Journal of …, 2022 - Elsevier
… potential of GK for protecting TH + neurons by multiple and … of dopaminergic neurons in the
MPTP mouse model of PD, and is … self-defenses by grafting astrocytes rejuvenates the aged …
MPTP mouse model of PD, and is … self-defenses by grafting astrocytes rejuvenates the aged …
Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model
… model for Parkinson disease recapitulates essential features of the disorder, including loss of
dopaminergic neurons … ability to protect against neurodegenerative disease and potentially …
dopaminergic neurons … ability to protect against neurodegenerative disease and potentially …
… -catenin signaling pathway governs a full program for dopaminergic neuron survival, neurorescue and regeneration in the MPTP mouse model of Parkinson's disease
B Marchetti - International journal of molecular sciences, 2018 - mdpi.com
… mouse model of basal ganglia injury uncovered, for the first time, a novel role for Wnt/β-catenin’s
main actors in the maintenance and protection of mDA neurons … levels to rejuvenate the …
main actors in the maintenance and protection of mDA neurons … levels to rejuvenate the …
[HTML][HTML] Nrf2/Wnt resilience orchestrates rejuvenation of glia-neuron dialogue in Parkinson's disease
B Marchetti - Redox biology, 2020 - Elsevier
… vivo murine models overexpressing human α-Syn WT or α-Syn A53T in wild type (Cx3cr1 +/+
) or deficient (Cx3cr1 −/− ) mice … , protected against rotenone-induced neurotoxicity in a rat …
) or deficient (Cx3cr1 −/− ) mice … , protected against rotenone-induced neurotoxicity in a rat …
[PDF][PDF] Reactive astrocytes are key players in nigrostriatal dopaminergic neurorepair in the MPTP mouse model of Parkinson's disease: focus on endogenous …
E Francesca, T Cataldo, T Nuccio, C Salvo… - Curr. Aging …, 2013 - researchgate.net
… ) and GSH than neurons, and can protect neurons from oxida… from astrocyte protects the
surrounding neurons from ROS and … nigral neurons in long-standing Parkinson's disease. Mov …
surrounding neurons from ROS and … nigral neurons in long-standing Parkinson's disease. Mov …
Prospects for new restorative and neuroprotective treatments in Parkinson's disease
SB Dunnett, A Björklund - Nature, 1999 - nature.com
… The recent revival of this … neurons after toxic, mechanical or ischaemic damage in the adult
brain. A wide range of factors can protect nigral dopamine neurons in vivo in animal models …
brain. A wide range of factors can protect nigral dopamine neurons in vivo in animal models …