Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
… and properties of α-synuclein aggregates in vitro and in vivo. One … on the aggregation kinetics
of α-synuclein in vitro using … steps in the aggregation of α-synuclein in the absence of any …
of α-synuclein in vitro using … steps in the aggregation of α-synuclein in the absence of any …
Cellular models of alpha‐synuclein toxicity and aggregation
…, JD Burgess, A Lamprokostopoulou… - Journal of …, 2019 - Wiley Online Library
… in vitro and in vivo experimental models mimicking α-synuclein pathology such as oligomerization,
toxicity and … of molecules capable of modulating α-synuclein toxicity. Here, we review …
toxicity and … of molecules capable of modulating α-synuclein toxicity. Here, we review …
Baicalein reduces E46K α‐synuclein aggregation in vitro and protects cells against E46K α‐synuclein toxicity in cell models of familiar Parkinsonism
M Jiang, Y Porat‐Shliom, Z Pei, Y Cheng… - Journal of …, 2010 - Wiley Online Library
… able to detect E46K-induced α-syn aggregates and toxicity. … aggregates both in vitro and
in cell cultures, and resulted in cell death. Baicalein decreased E46K α-syn aggregation in vitro …
in cell cultures, and resulted in cell death. Baicalein decreased E46K α-syn aggregation in vitro …
In vitro aggregation assays for the characterization of α-synuclein prion-like properties
… These aggregates may be uptaken and propagated … of α-synuclein aggregation in vitro,
as well as crucial factors affecting this process. We also describe how PD-linked α-synuclein …
as well as crucial factors affecting this process. We also describe how PD-linked α-synuclein …
Geldanamycin induces Hsp70 and prevents α-synuclein aggregation and toxicity in vitro
… induced toxicity in human H4 neuroglioma cells. Here, we hypothesize that GA treatment
will reduce α-synuclein aggregation and prevent α-synuclein induced toxicity and we show that …
will reduce α-synuclein aggregation and prevent α-synuclein induced toxicity and we show that …
Potential role of natural polyphenols against protein aggregation toxicity: in vitro, in vivo, and clinical studies
G Henríquez, A Gomez, E Guerrero… - ACS Chemical …, 2020 - ACS Publications
… , α-synuclein, and mutant Huntingtin which participate in the formation, accumulation,
and deposition of toxic misfolded aggregates… inhibit aggregation of amyloid β, tau, and α-synuclein …
and deposition of toxic misfolded aggregates… inhibit aggregation of amyloid β, tau, and α-synuclein …
α‐Synuclein and Parkinson's disease: Selective neurodegenerative effect of α‐synuclein fragment on dopaminergic neurons in vitro and in vivo
G Forloni, I Bertani, AM Calella, F Thaler… - Annals of …, 2000 - Wiley Online Library
… the potential neurotoxic effects of -synuclein aggregation and might help in … synuclein
fragment NAC was neurotoxic and selectively induced DA neurodegeneration in vitro and in vivo…
fragment NAC was neurotoxic and selectively induced DA neurodegeneration in vitro and in vivo…
[HTML][HTML] Hsp70 reduces α-synuclein aggregation and toxicity
… α-synuclein in an α-synuclein transgenic mouse model and in an in vitro model of α-synuclein
aggregation… Hsp70 into the in vivo model by breeding α-synuclein transgenic mice with …
aggregation… Hsp70 into the in vivo model by breeding α-synuclein transgenic mice with …
[HTML][HTML] The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity
O Khalaf, B Fauvet, A Oueslati, I Dikiy… - Journal of Biological …, 2014 - ASBMB
… structure, aggregation, fibril formation, and membrane binding of monomeric α-Syn in vitro
using … (CD), and a battery of imaging and aggregation assays. To determine how this mutation …
using … (CD), and a battery of imaging and aggregation assays. To determine how this mutation …
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev… - Proceedings of the …, 2017 - National Acad Sciences
… quantitative in vitro assays, we identify a compound, squalamine, that blocks α-synuclein
aggregation, … Our results show that squalamine, by competing with α-synuclein for binding lipid …
aggregation, … Our results show that squalamine, by competing with α-synuclein for binding lipid …
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