β-Casein is a cow's milk protein that occurs predominantly in two forms, A1 and A2.
Epidemiological evidence suggests that per capita consumption of β-casein A1 is
associated with national mortality rates from ischaemic heart disease. A biological
mechanism was proposed after rabbits fed diets containing β-casein A2 had lower serum
cholesterol concentrations and less aortic intimal thickening than rabbits fed β-casein A1.
We tested whether β-casein A1 and A2 variants differentially affect plasma cholesterol …