… PCR techniques, we analyzed the mitochondrial DNA (mtDNA) isolated from the heart … Okb
deletion was found in the heart mtDNA of one HCM patient, while no … aging human tissues. …

… Accumulation of mitochondrial DNA deletions in the malignant … study using laser-captured
microdissected tissues. … stress in human cells harboring 4,977 bp-deleted mitochondrial DNA. …

… inducing mutations in mitochondrial DNA (mtDNA) and play … Blood and brain tissue samples
collected from experimental … -syn accumulation and alterations in mitochondrial processes …

… is linked to the mutations of mitochondrial DNA (mtDNA) in … , aging is progressive accumulation
through life of many random molecular defects that build up within the cells and tissues. …

… To illustrate this, our research on mitochondrial DNA (mtDNA) … due to clonal expansion of
deletion mutants are in part due … Sampling human brain tissue at regular intervals over several …

… in expression upon Dnmt1 deletion. Among them Pak6 coding … relevance of DNA methylation
and demethylation for the age-… , impaired DNA repair, and the accumulation of nuclear and …

… lipids, proteins, and nucleic acids accumulate in brain tissues of PD patients. … somatic
deletions in mitochondrial DNA (mtDNA), in the substantia nigra of PD patients compared to age…

… The accumulation of mtDNA mutations impairs the electron … tissue-specific effects of CR
include the prevention of the age… mitochondrial impairments ranging from mitochondrial DNA (…

… Because somatic mutations in neurons accumulate … A new mutation at exon 17, named the
Uppsala deletion, increases … mechanisms as all other of our tissues and cell types. This way, …

… more somatic mutations in the mitochondrial DNA (mtDNA) … tissue, as well as biopsy
samples of a variety of tissues, … Accumulation of nuclear and mitochondrial DNA damage in the …