… pain, such as spared nerve injury, spinal nerve ligation, and … facilitate chronic pain development
in both sexes, but inhibiting … that activate microglia in the dorsal horn of the spinal cord. …

… chronic pain. Therefore, there is an urgent need for new … Activated microglia leads to
functional changes including … peripheral nerve injury-induced spinal cord degeneration and …

… Additionally, we address the intricacies of chronic pain … pain, known as spared nerve
injury (SNI), microglia are … by activated microglia, leading to the subsequent release of IL-1β, …

… attenuation of skeletal muscle loss following spinal cord injury. … chronic pain and permanent
damages after experiencing … reactive responses recruiting activated microglial cells due to …

… come from less physical activity, social isolation, chronic pain… underlie this important spinal
cord injury consequence. Finally… SCI not only activated microglia, the resident immune cells of …

… Chronic pain is sustained by a phenomenon of hyper-… cause of nerve damage, eg traumatic
nerve injury is associated with … native microglia and macrophages is described as pivotal for …

… for ERK5 activation in the microglia after nerve injuries. The … In addition, activated microglia
in the spinal cord contributes … of ERK5 during the pathological process of chronic pain. …

… of activated microglia appears to be linked to change from an … role of cathepsin B in chronic
pain generation, because both IL-… -IL-1β processing in the spinal cord following nerve injury. …

… complex milieu of spinal cord injury lesion pathobiology and … Multiple changes in expression
occur in activated microglia that affect … drive allodynia and chronic pain cascades. While this …

… in the development of a chronic pain state. Recent use of unbiased … that following local nerve
injury, the ability to evoke a pain state … In the spinal cord, activated microglia and adaptive, …