Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing
PR Somanath, J Chen, TV Byzova - Angiogenesis, 2008 - Springer
… matrix composition, and angiogenesis in tumors. Hence, we hypothesized that Akt1 may
be necessary for other angiogenesis-dependent processes, including wound healing. Using …
be necessary for other angiogenesis-dependent processes, including wound healing. Using …
Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
J Chen, PR Somanath, O Razorenova, WS Chen… - Nature medicine, 2005 - nature.com
… Akt1 is the predominant isoform in vascular cells and describe the unexpected consequences
of Akt1 knockout on vascular … As cell migration is an essential step in angiogenic response, …
of Akt1 knockout on vascular … As cell migration is an essential step in angiogenic response, …
[HTML][HTML] Akt1 in endothelial cell and angiogenesis
PR Somanath, OV Razorenova, J Chen… - Cell cycle …, 2006 - ncbi.nlm.nih.gov
… of increased angiogenesis in the Akt1 −/− mice: changes in vascular permeability; a thinner
… a partial recovery. As eNOS has been shown to be necessary for blood vessel maturation, 68 …
… a partial recovery. As eNOS has been shown to be necessary for blood vessel maturation, 68 …
[HTML][HTML] Akt1 controls insulin-driven VEGF biosynthesis from keratinocytes: implications for normal and diabetes-impaired skin repair in mice
I Goren, E Müller, D Schiefelbein, P Gutwein… - Journal of Investigative …, 2009 - Elsevier
… of vascular endothelial growth factor (VEGF) protein in chronic … important to note that the
reduction in phosphorylated Akt in … of keratinocyte angiogenic potential in wound healing. As a …
reduction in phosphorylated Akt in … of keratinocyte angiogenic potential in wound healing. As a …
Akt takes center stage in angiogenesis signaling
S Dimmeler, AM Zeiher - Circulation research, 2000 - Am Heart Assoc
… during embryonic blood vessel formation is required for … did promote vascular network
maturation, when coadministered with … showing that, during embryonic development, Ang1 plays a …
maturation, when coadministered with … showing that, during embryonic development, Ang1 plays a …
AKT signaling in regulating angiogenesis
BH Jiang, LZ Liu - Current cancer drug targets, 2008 - ingentaconnect.com
… approach for targeting angiogenesis, which could be important for the development of new
… AKT1 is the predominant isoform in vascular cells. Recently, impaired vascular maturation …
… AKT1 is the predominant isoform in vascular cells. Recently, impaired vascular maturation …
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
MY Lee, AK Luciano, E Ackah… - Proceedings of the …, 2014 - National Acad Sciences
… postnatal Akt1 deletion confers significant retinal vascular … that Akt1 is the predominant
Akt isoform in ECs necessary for … vascular development was also assessed in global Akt1-null …
Akt isoform in ECs necessary for … vascular development was also assessed in global Akt1-null …
Role of Akt signaling in vascular homeostasis and angiogenesis
I Shiojima, K Walsh - Circulation research, 2002 - Am Heart Assoc
… crucial mediators of vascular development, considerable progress … of angiogenesis at sites
of tissue growth and/or repair. A … attachment is required for growth factors to activate Akt and …
of tissue growth and/or repair. A … attachment is required for growth factors to activate Akt and …
Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair
KE Johnson, TA Wilgus - Advances in wound care, 2014 - liebertpub.com
… of a complex vascular network required for embryonic development. Vasculogenesis can …
VEGFR phosphorylation triggers PI3K activation and phosphorylation of Akt. Active Akt blocks …
VEGFR phosphorylation triggers PI3K activation and phosphorylation of Akt. Active Akt blocks …
The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo
… Akt site, S 1176 , is critical for many of the vascular actions of … Our results in wound healing
and limb ischemia point toward … the predominant Akt substrate necessary for angiogenesis; …
and limb ischemia point toward … the predominant Akt substrate necessary for angiogenesis; …